Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

doi:10.1038/mp.2017.229

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	Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors
	Jun, M.1,2,3; Xiaolong, Q.2; Chaojuan, Y.4; Ruiyuan, P.2; Shukun, W.1; Junbing, W.2; Li, H.2; Hong, C.2; Jinbo, C.1; Rong, W.1
刊名	MOLECULAR PSYCHIATRY
	2018-04-01
卷号	23 期号:4 页码:883-891
ISSN号	1359-4184
DOI	10.1038/mp.2017.229
英文摘要	Extracellular ATP is a widespread cell-to-cell signaling molecule in the brain, where it functions as a neuromodulator by activating glia and neurons. Although ATP exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of ATP release remain to be elaborated. Here, we define Calhm2 as an ATP-releasing channel protein based on in vitro and in vivo models. Conventional knockout and conditional astrocyte knockout of Calhm2 both lead to significantly reduced ATP concentrations, loss of hippocampal spine number, neural dysfunction and depression-like behaviors in mice, which can be significantly rescued by ATP replenishment. Our findings identify Calhm2 as a critical ATP-releasing channel that modulates neural activity and as a potential risk factor of depression.
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000428161500012
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45783]
专题	中国科学院化学研究所
通讯作者	Jun, M.
作者单位	1.Care of Yuan Z, Beijing Inst Basic Med Sci, Brain Sci Ctr, 27 Taiping Rd, Beijing 100039, Peoples R China 2.Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing, Peoples R China 3.China Med Univ, Aviat Gen Hosp, Dept Anesthesiol Pain Med & Crit Care Med, Beijing, Peoples R China 4.Peking Univ, Sch Life Sci, State Key Lab Membrane Biol, Beijing, Peoples R China 5.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing, Peoples R China 6.Natl Inst Biol Sci, Beijing, Peoples R China 7.Zhejiang Univ, Sch Med, Dept Neurol, Hangzhou, Zhejiang, Peoples R China 8.Zhejiang Univ, Res Ctr Neurol, Affiliated Hosipital 2, Sch Med, Hangzhou, Zhejiang, Peoples R China 9.Zhejiang Univ, Sch Med, Collaborat Innovat Ctr Brain Sci, Hangzhou, Zhejiang, Peoples R China 10.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jun, M.,Xiaolong, Q.,Chaojuan, Y.,et al. Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors[J]. MOLECULAR PSYCHIATRY,2018,23(4):883-891.
APA	Jun, M..,Xiaolong, Q..,Chaojuan, Y..,Ruiyuan, P..,Shukun, W..,...&Zengqiang, Y..(2018).Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors.MOLECULAR PSYCHIATRY,23(4),883-891.
MLA	Jun, M.,et al."Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors".MOLECULAR PSYCHIATRY 23.4(2018):883-891.