Piperazine multi-substituted triarylboron compound as an aqueous soluble fluorescent probe for imaging nucleoli, nuclear matrix and nuclear membrane

doi:10.1016/j.snb.2018.01.161

CORC > 化学研究所 > 中国科学院化学研究所

	Piperazine multi-substituted triarylboron compound as an aqueous soluble fluorescent probe for imaging nucleoli, nuclear matrix and nuclear membrane
	Liu, Jun 1,2; Li, Shuang 3; Zhang, Shilu 1,2; Shen, Chengyi 1,2; Zhu, Jiang 1,2; Yang, Guoqiang 3; Zhang, Xiaoming 1,2,4
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2018-05-15
卷号	261 页码:531-536
关键词	Triarylboron Compounds Fluorescence Nucleolar Nuclear Matrix Nuclear Membrane
ISSN号	0925-4005
DOI	10.1016/j.snb.2018.01.161
英文摘要	The nucleus is composed of the nuclear membrane, nuclear matrix, and nucleolus. To achieve simultaneous fluorescence imaging of multiple compartments of the nuclear, we synthesized TAB-piperazine-1 and TAB-piperazine-2 by functionalizing triarylboron with different structures using two or three piperazine groups, respectively. The probes can bind with RNA and be transferred from a high-polarity aqueous medium to lower-polarity RNA. After that, the polarity-sensitive TAB-piperazine-2 produced a ratio metric readout, accompanied by a noticeable color change from yellow to cyan, demonstrating more beneficial properties than TAB-piperazine-1. TAB-piperazine-2 can also be used for imaging the three compartments of the nuclear and analyzing their microenvironment polarity. (C) 2018 Published by Elsevier B.V.
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000426437400064
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45777]
专题	中国科学院化学研究所
通讯作者	Zhu, Jiang; Yang, Guoqiang; Zhang, Xiaoming
作者单位	1.North Sichuan Med Coll, Sch Preclin Med, Sichuan Key Lab Med Imaging, Nanchong 637000, Peoples R China 2.North Sichuan Med Coll, Sch Preclin Med, Dept Chem, Nanchong 637000, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Photochem, Beijing 100190, Peoples R China 4.North Sichuan Med Coll, Dept Radiol, Affiliated Hosp, Nanchong 637000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jun,Li, Shuang,Zhang, Shilu,et al. Piperazine multi-substituted triarylboron compound as an aqueous soluble fluorescent probe for imaging nucleoli, nuclear matrix and nuclear membrane[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,261:531-536.
APA	Liu, Jun.,Li, Shuang.,Zhang, Shilu.,Shen, Chengyi.,Zhu, Jiang.,...&Zhang, Xiaoming.(2018).Piperazine multi-substituted triarylboron compound as an aqueous soluble fluorescent probe for imaging nucleoli, nuclear matrix and nuclear membrane.SENSORS AND ACTUATORS B-CHEMICAL,261,531-536.
MLA	Liu, Jun,et al."Piperazine multi-substituted triarylboron compound as an aqueous soluble fluorescent probe for imaging nucleoli, nuclear matrix and nuclear membrane".SENSORS AND ACTUATORS B-CHEMICAL 261(2018):531-536.