Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion

doi:10.1002/anie.201712795

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	Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion
	Gao, Yunpeng 1,2; Wu, Guojiao 1,2; Zhou, Qi 1,2; Wang, Jianbo 1,2,3
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2018-03-01
卷号	57 期号:10 页码:2716-2720
关键词	Carbenes Cross-coupling Oxidation Palladium Ynamides
ISSN号	1433-7851
DOI	10.1002/anie.201712795
英文摘要	A palladium-catalyzed oxygenative cross-coupling of ynamides and benzyl bromides has been developed. After subsequent hydrogenation, ,-disubstituted amide derivatives were obtained in good yields. Migratory insertion of -oxo palladium carbene species, generated by intermolecular oxidation, is proposed as the key step in this reaction. The study demonstrates the potential of ynamides to serve as carbene precursors in palladium-catalyzed C-C bond-forming cross-coupling reactions.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000426252400035
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45699]
专题	中国科学院化学研究所
通讯作者	Wang, Jianbo
作者单位	1.Peking Univ, Coll Chem, Minist Educ, BNLMS, Beijing 100871, Peoples R China 2.Peking Univ, Coll Chem, Minist Educ, Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Gao, Yunpeng,Wu, Guojiao,Zhou, Qi,et al. Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(10):2716-2720.
APA	Gao, Yunpeng,Wu, Guojiao,Zhou, Qi,&Wang, Jianbo.(2018).Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(10),2716-2720.
MLA	Gao, Yunpeng,et al."Palladium-Catalyzed Oxygenative Cross-Coupling of Ynamides and Benzyl Bromides by Carbene Migratory Insertion".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.10(2018):2716-2720.