Revealing membrane permeability of polymersomes through fluorescence enhancement

doi:10.1016/j.colsurfb.2017.10.058

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	Revealing membrane permeability of polymersomes through fluorescence enhancement
	Quan, Li 1; Ding, Hongyan 1; Pan, Changjiang 1; Wei, Yanchun 1; Xie, Zhigang 2
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2018
卷号	161 页码:156-161
关键词	Fluorescence Polymersomes Permeability Bodipy
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2017.10.058
英文摘要	In this work, permeability of polymersomes was quantified by fluorescence enhancement. The polymersomes were prepared from poly(ethylene glycol)-b-poly(epsilon-caprolactone)(PEG-PCL), and an acid sensitive hydrophobic dye borondipyrromethene (BODIPY) was encapsulated into the membrane of polymersomes. H+ from trifluoroacetic acid (TFA) would diffuse into the membrane of polymersomes to enhance the fluorescence of BODIPY. Intensity of the enhanced fluorescence could be used for quantifying the H+ permeability of polymersomes. In addition, poly(epsilon-caprolactone) (PCL) was used to control the permeability ability of the membrane. Such quantitative information on the molecular diffusion of polymersomes is of fundamental importance to many of their potential applications, e.g., nanoreactors and drug delivery. (C) 2017 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000423636100019
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45505]
专题	中国科学院化学研究所
通讯作者	Pan, Changjiang; Xie, Zhigang
作者单位	1.Huaiyin Inst Technol, Jiangsu Prov Key Lab Intervent Med Device, Huaian 223003, Jiangsu, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Quan, Li,Ding, Hongyan,Pan, Changjiang,et al. Revealing membrane permeability of polymersomes through fluorescence enhancement[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2018,161:156-161.
APA	Quan, Li,Ding, Hongyan,Pan, Changjiang,Wei, Yanchun,&Xie, Zhigang.(2018).Revealing membrane permeability of polymersomes through fluorescence enhancement.COLLOIDS AND SURFACES B-BIOINTERFACES,161,156-161.
MLA	Quan, Li,et al."Revealing membrane permeability of polymersomes through fluorescence enhancement".COLLOIDS AND SURFACES B-BIOINTERFACES 161(2018):156-161.