Multi-Targeted Anticancer Agents

doi:10.2174/1568026617666170707124126

CORC > 化学研究所 > 中国科学院化学研究所

	Multi-Targeted Anticancer Agents
	Zheng, Wei 1,2,3; Zhao, Yao 1,2,3; Luo, Qun 1,2,3,4; Zhang, Yang 1,2,3; Wu, Kui 1,2,3; Wang, Fuyi 1,2,3,4
刊名	CURRENT TOPICS IN MEDICINAL CHEMISTRY
	2017
卷号	17 期号:28 页码:3084-3098
关键词	Anticancer Agents Multi-targeting Drug Development Precision Medicine Bcr-abl Cytotoxic Anticancer Drug
ISSN号	1568-0266
DOI	10.2174/1568026617666170707124126
英文摘要	There is a great demand for the development of novel anticancer drugs, due to the increasing morbidity and high mortality of cancer. To date, chemotherapy still plays a central role in the clinical treatment of cancer, but this role is being reduced by targeted therapies. Since cancer is a complicated and multiple genes involved disease, drugs that act at multiple targets can enhance efficacy and lower drug resistance, and are thought to be the future of novel anticancer drug development. In this paper, we discuss the recent development of "single molecule, multi-target" anticancer agents that combine two or more pharmacophores in a single molecule, including organic multitargeted anticancer agents and metal based complexes such as platinum, ruthenium, iridium and rhodium complexes. These efforts will contribute to clinical cancer therapy and benefit patients in the future.
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000415882700002
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45309]
专题	中国科学院化学研究所
通讯作者	Zhao, Yao; Wang, Fuyi
作者单位	1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Wei,Zhao, Yao,Luo, Qun,et al. Multi-Targeted Anticancer Agents[J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY,2017,17(28):3084-3098.
APA	Zheng, Wei,Zhao, Yao,Luo, Qun,Zhang, Yang,Wu, Kui,&Wang, Fuyi.(2017).Multi-Targeted Anticancer Agents.CURRENT TOPICS IN MEDICINAL CHEMISTRY,17(28),3084-3098.
MLA	Zheng, Wei,et al."Multi-Targeted Anticancer Agents".CURRENT TOPICS IN MEDICINAL CHEMISTRY 17.28(2017):3084-3098.