Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration

doi:10.1016/j.cclet.2017.07.014

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	Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration
	Ren, Hui-Hui 1,2; Zhao, Hui-Yu 3; Cui, Yang 1,2; Ao, Xiang 3; Li, Ai-Ling 1; Zhang, Zhong-Min 3; Qiu, Dong 1,2
刊名	CHINESE CHEMICAL LETTERS
	2017-11-01
卷号	28 期号:11 页码:2116-2120
关键词	Bioactive Glasses Composites Mechanical Properties Bioactivity Poly(1 8-octanediol-co-citrate)
ISSN号	1001-8417
DOI	10.1016/j.cclet.2017.07.014
英文摘要	Poly(1,8-octanediol-co-citrate) (POC) represents a new promising biocompatible and biodegradable polyester that has been extensively investigated for soft tissue engineering. However, the poor mechanical performance and poor bioactivity limit its application in bone regeneration. In this study, a series of POC/bioactive glasses (BG) composites were developed using 45S5 Bioglass (R) and a phytic acid-derived bioactive glass (referred as PSC). The results indicated that calcium in BG could enhance the crosslinking of the POC/BG composites by forming calcium dicarboxylate bridges and thus improve their mechanical performances. When PSC were used, the composites exhibited significantly better mechanical properties compared to composites with 45S5 Bioglass (R). For example, by incorporating 70 wt% PSC, the compressive strength of POC/PSC composites could be improved to approximately 50 MPa and modulus 13 +/- 0.1 GPa. Furthermore, all these POC/PSC composites showed good in vitro bioactivity and cellular biocompatibility. Histology results in femoral condyle defects of Sprague-Dawley rats indicated that the POC/PSC samples integrated well with surrounding tissues and stimulated bone regeneration. The improved mechanical properties and bioactivity of POC/PSC composites make them promising for potential application in bone regeneration. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000417962800013
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45213]
专题	中国科学院化学研究所
通讯作者	Zhang, Zhong-Min; Qiu, Dong
作者单位	1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 3.Southern Med Univ, Dept Orthoped, Affiliated Hosp 3, Guangzhou 570665, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Ren, Hui-Hui,Zhao, Hui-Yu,Cui, Yang,et al. Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration[J]. CHINESE CHEMICAL LETTERS,2017,28(11):2116-2120.
APA	Ren, Hui-Hui.,Zhao, Hui-Yu.,Cui, Yang.,Ao, Xiang.,Li, Ai-Ling.,...&Qiu, Dong.(2017).Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration.CHINESE CHEMICAL LETTERS,28(11),2116-2120.
MLA	Ren, Hui-Hui,et al."Poly(1,8-octanediol citrate)/bioactive glass composite with improved mechanical performance and bioactivity for bone regeneration".CHINESE CHEMICAL LETTERS 28.11(2017):2116-2120.