Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers

doi:10.1021/acsami.7b12395

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	Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers
	Wang, Haozheng 1,2; Xu, Xiaodong 3; Chen, Runhai 1; Zhao, Jiruo 2; Cui, Lele 3; Sheng, Guangkuo 3; Shi, Qiang 1; Wong, Shing-Chung 4; Yin, Jinghua 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2017-11-08
卷号	9 期号:44 页码:38313-38322
关键词	Antioxidant Defense System Oxidative Injure Pluronic P127 Red Blood Cells Reactive Electrospinning
ISSN号	1944-8244
DOI	10.1021/acsami.7b12395
英文摘要	Cells were continuously exposed to oxidative damage by overproduction of reactive oxygen species (ROS) when they contacted implanted biomaterials. The strategy to prevent cells from oxidative injures remains a challenge.. Inspired by the antioxidant defense system of cells, we constructed a biocompatible and ROS-responsive architecture on the substrate of styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS). The strategy was based on fabrication of architectures through reactive electrospinning of mixture including SEBS, acylated Pluronic F127, copolymer of poly(ethylene glycol) diacrylate and 1,2-ethanedithiol (PEGDA-EDT), and antioxidants (AA-2G) and ROS-triggered release of AA-2G from microfibers to detoxify the excess ROS. We demonstrated that the stable and hydrophilic architecture was constructed by phase separation of SEBS/F127 components and cross-linking between polymer chains during electrospinning; the ROS-responsive fibers controlled the release of AA-2G and the interaction of AA-2G with ROS reduced the oxidative damage to cells. The bioinspirecl architecture not only reduced mechanical and oxidative damage to cells but also maintained normal ROS level for physiological hemostasis. This work provides basic principles to design and develop antioxidative biomaterials for implantation in vivo.
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000415140800018
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/45067]
专题	中国科学院化学研究所
通讯作者	Zhao, Jiruo; Shi, Qiang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Minist Educ Shandong, Key Lab Rubber Plast QUST, Shandong Prov Key Lab Olefin Catalysis & Polymeri, Qingdao 266042, Peoples R China 3.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Key Lab Superlight Mat & Surface Technol, Minist Educ, Harbin 150001, Heilongjiang, Peoples R China 4.Univ Akron, Dept Mech Engn, Akron, OH 44325 USA
推荐引用方式 GB/T 7714	Wang, Haozheng,Xu, Xiaodong,Chen, Runhai,et al. Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(44):38313-38322.
APA	Wang, Haozheng.,Xu, Xiaodong.,Chen, Runhai.,Zhao, Jiruo.,Cui, Lele.,...&Yin, Jinghua.(2017).Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers.ACS APPLIED MATERIALS & INTERFACES,9(44),38313-38322.
MLA	Wang, Haozheng,et al."Bioinspired Antioxidant Defense System Constructed by Antioxidants-Eluting Electrospun F127-Based Fibers".ACS APPLIED MATERIALS & INTERFACES 9.44(2017):38313-38322.