Solvent-dependent structural dynamics of an azido-platinum complex revealed by linear and nonlinear infrared spectroscopy

doi:10.1039/c7cp08606g

CORC > 化学研究所 > 中国科学院化学研究所

	Solvent-dependent structural dynamics of an azido-platinum complex revealed by linear and nonlinear infrared spectroscopy
	He, Xuemei 1,2; Xu, Fengmin 2,3; Yu, Pengyun 1,2; Wu, Yanzhou 1,2; Wang, Fuyi 2,3; Zhao, Yao 3; Wang, Jianping 1,2
刊名	PHYSICAL CHEMISTRY CHEMICAL PHYSICS
	2018-04-21
卷号	20 期号:15 页码:9984-9996
ISSN号	1463-9076
DOI	10.1039/c7cp08606g
英文摘要	The vibrational and anisotropic relaxation dynamics and structural dynamics of a potential anticancer prodrug, trans,trans,trans-[Pt(N-3)(2)(OH)(2)(py)(2)], were investigated using time-resolved infrared pump-probe spectroscopy and ultrafast two-dimensional infrared (2D IR) spectroscopy. Herein, two representative bio-friendly solvents, H2O and DMSO, were used, in which the local structural and dynamical variations were monitored using the antisymmetric linear combination of the two N-3 stretching vibrational modes as an infrared probe. It was found that the vibrational relaxation process of the N-3 antisymmetric stretching (as) mode in H2O is two to three times faster than that in DMSO. The anisotropic relaxation process of the anticancer prodrug was observed to be hindered in DMSO; this indicated a tighter solvent environment around the sample molecule in this solvent. The vibrational frequency time correlation of the N-3 antisymmetric stretching mode in H2O decays with a time constant of 1.94 ps, in agreement with the hydrogen bond formation and breaking times of water. In DMSO, the frequency time correlation of the N-3 as mode decays on a much longer time scale; this further indicates its sensitivity to the out-layer DMSO structural dynamics, which are relatively static in the experimental time window.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000430537600031
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43261]
专题	中国科学院化学研究所
通讯作者	Zhao, Yao; Wang, Jianping
作者单位	1.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Mol React Dynam Lab, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci,Beijing Natl, CAS Key Lab Analyt Chem Living Biosyst,Natl Ctr M, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	He, Xuemei,Xu, Fengmin,Yu, Pengyun,et al. Solvent-dependent structural dynamics of an azido-platinum complex revealed by linear and nonlinear infrared spectroscopy[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2018,20(15):9984-9996.
APA	He, Xuemei.,Xu, Fengmin.,Yu, Pengyun.,Wu, Yanzhou.,Wang, Fuyi.,...&Wang, Jianping.(2018).Solvent-dependent structural dynamics of an azido-platinum complex revealed by linear and nonlinear infrared spectroscopy.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,20(15),9984-9996.
MLA	He, Xuemei,et al."Solvent-dependent structural dynamics of an azido-platinum complex revealed by linear and nonlinear infrared spectroscopy".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 20.15(2018):9984-9996.