Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering

doi:10.1007/s10118-018-2079-x

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	Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering
	Shi, Xu-Dong 1,2; Sun, Pei-Jian 2; Gan, Zhi-Hua 2,3
刊名	CHINESE JOURNAL OF POLYMER SCIENCE
	2018-06-01
卷号	36 期号:6 页码:712-719
关键词	Polylactide Porous Microspheres Drug Release Cell Tissue Engineering
ISSN号	0256-7679
DOI	10.1007/s10118-018-2079-x
英文摘要	In this study, porous polylactide (PLA) microspheres with different structures were prepared through the multiple emulsion solvent evaporation method. By changing organic solvents (ethyl acetate and chloroform) and adding effervescent salt NH4HCO3 in the inner water phase, microspheres with porous capsular, matrix, microcapsular and multivesicular structures were prepared. The protein encapsulation and release, and the cell growth behavior of porous microspheres were further explored. Under the same inner water phase, microspheres prepared with chloroform had higher protein encapsulation efficiency and less protein release rate as compared with those prepared with ethyl acetate. Cell experiments showed that the relatively rough surface of microspheres prepared with chloroform was more favorable for the cell growth in comparison with the smooth surface of microspheres prepared with ethyl acetate. This study shows a simple and effective method to control the protein release and cell growth behaviors of polymer microspheres by tuning their porous structure.
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000431664900004
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43147]
专题	中国科学院化学研究所
通讯作者	Gan, Zhi-Hua
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 3.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Shi, Xu-Dong,Sun, Pei-Jian,Gan, Zhi-Hua. Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2018,36(6):712-719.
APA	Shi, Xu-Dong,Sun, Pei-Jian,&Gan, Zhi-Hua.(2018).Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering.CHINESE JOURNAL OF POLYMER SCIENCE,36(6),712-719.
MLA	Shi, Xu-Dong,et al."Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering".CHINESE JOURNAL OF POLYMER SCIENCE 36.6(2018):712-719.