A facile method for preparation of uniform polymeric vesicles with tunable size

doi:10.1039/c8nr02901f

CORC > 化学研究所 > 中国科学院化学研究所

	A facile method for preparation of uniform polymeric vesicles with tunable size
	Wu, Ming 1,2; Wang, Yingying 1,2; Han, Yuanyuan 1; Cui, Jie 1; Jiang, Wei 1
刊名	NANOSCALE
	2018-08-21
卷号	10 期号:31 页码:14860-14867
ISSN号	2040-3364
DOI	10.1039/c8nr02901f
英文摘要	Vesicle size and size uniformity determine whether the vesicle can realize its full potential in a wide range of biological and biomedical applications. Herein, we reported a simple yet general cosolvent method to directly prepare uniform polymeric vesicles with a tunable size ranging from 100 nm to 150 nm formed from the amphiphilic diblock copolymer poly(4-vinylpyridine)-block-polystyrene (P4VP(77)-b-PS318). The uniform polymeric vesicles can be easily obtained by adding plenty of selective solvent only once into the polymer solution and then resting overnight. It is found that uniform vesicles are formed with a fixed size. There is no further fusion between vesicles. The PDI of the vesicles measured by DLS can be as low as 0.03. Moreover, the size of these uniform vesicles can be controlled by the content of the selective solvent. The higher the content of the selective solvent, the smaller the vesicles that form. Monte Carlo simulation was also performed in this study. The simulation results indicated that the vesicle size indeed decreases with an increase in the content of the selective solvent. Two reasons leading to the decrease in vesicle size are elucidated. In addition, the simulations reveal that the size uniformity of the vesicle is essentially determined by the interactive enthalpy of the system.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000445709600010
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/43023]
专题	中国科学院化学研究所
通讯作者	Han, Yuanyuan; Jiang, Wei
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wu, Ming,Wang, Yingying,Han, Yuanyuan,et al. A facile method for preparation of uniform polymeric vesicles with tunable size[J]. NANOSCALE,2018,10(31):14860-14867.
APA	Wu, Ming,Wang, Yingying,Han, Yuanyuan,Cui, Jie,&Jiang, Wei.(2018).A facile method for preparation of uniform polymeric vesicles with tunable size.NANOSCALE,10(31),14860-14867.
MLA	Wu, Ming,et al."A facile method for preparation of uniform polymeric vesicles with tunable size".NANOSCALE 10.31(2018):14860-14867.