Construction of anti-thrombotic and anti- oxidative surfaces with elastomer/Pluronic F127 assembled microfibers

doi:10.1016/j.apsusc.2018.04.243

CORC > 化学研究所 > 中国科学院化学研究所

	Construction of anti-thrombotic and anti- oxidative surfaces with elastomer/Pluronic F127 assembled microfibers
	Xu, Xiaodong 1; Liu, Jingchuan 2; Sheng, Guangkuo 1,2; Chen, Runhai 2; Zhao, Jie 3; Liu, Xiaoju 4; Shi, Qiang 2; Yin, Jinghua 2
刊名	APPLIED SURFACE SCIENCE
	2018-09-01
卷号	451 页码:76-85
关键词	Anti-oxidative Anti-thrombotic Hemocompatible Pluronic F127 Electrospinning
ISSN号	0169-4332
DOI	10.1016/j.apsusc.2018.04.243
英文摘要	The thrombus formation and oxidation of blood components caused by blood-contacting biomaterials were main reasons for poor hemocompatibility of biomaterials. To construct the anti-thrombotic and anti-oxidative surface, we electrospun styrene-b-(ethylene-co-butylene)-b-styrene elastomer (SEBS)/acylated Pluronic F127 (A-F127)/L-ascorbic acid (AA) microfibers based on the SEBS substrate in one step. Our strategy was based on that the phase-separation between SEBS and A-F127 during electrospinning resulted in hydrophilic surface of microfibers, the crosslinking of electrospun meshes rendered the surface stable, and the AA release from the microfibers interacted with blood cells actively to prevent blood cells from oxidative damage. We demonstrated that the self-assembly of SEBS/A-F127 blends resulted in the similar structure as core-shell microfibers with the A-F127 richness in the sheath; the presence of AF127 on the out layer made the microfibers hydrophilic and rendered the microfibers anti-thrombotic; the release of AA from the microfibers in the PBS solution was temperature-dependent; AA acted as the antioxidant to decrease the oxidative damage of blood cells after long-term contact between biomaterials and blood. Our work paves a new way to develop long-term hemocompatible biomaterials, which may be helpful to prevent blood cells from oxidative damage to maintain the normal function of blood cells in vivo. (C) 2018 Elsevier B.V. All rights reserved.
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000433200700008
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42713]
专题	中国科学院化学研究所
通讯作者	Shi, Qiang
作者单位	1.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 3.Jilin Univ, Minist Educ, Key Lab Bion Engn, Changchun 130022, Jilin, Peoples R China 4.Jilin Univ, Hosp 2, Changchun 130041, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiaodong,Liu, Jingchuan,Sheng, Guangkuo,et al. Construction of anti-thrombotic and anti- oxidative surfaces with elastomer/Pluronic F127 assembled microfibers[J]. APPLIED SURFACE SCIENCE,2018,451:76-85.
APA	Xu, Xiaodong.,Liu, Jingchuan.,Sheng, Guangkuo.,Chen, Runhai.,Zhao, Jie.,...&Yin, Jinghua.(2018).Construction of anti-thrombotic and anti- oxidative surfaces with elastomer/Pluronic F127 assembled microfibers.APPLIED SURFACE SCIENCE,451,76-85.
MLA	Xu, Xiaodong,et al."Construction of anti-thrombotic and anti- oxidative surfaces with elastomer/Pluronic F127 assembled microfibers".APPLIED SURFACE SCIENCE 451(2018):76-85.