Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes

doi:10.1039/c8ob00981c

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	Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes
	Tan, Jing 1; Ni, Penghui 1; Huang, Huawen 1; Deng, Guo-Jun 1,2,3
刊名	ORGANIC & BIOMOLECULAR CHEMISTRY
	2018-06-21
卷号	16 期号:23 页码:4227-4230
ISSN号	1477-0520
DOI	10.1039/c8ob00981c
英文摘要	The elemental sulfur-promoted oxidative cyclization reaction for the efficient synthesis of substituted imidazo[1,2-a]pyridines has been developed. Easily available 2-aminopyridines and aldehydes were directly assembled in a highly atom-economical fashion through oxidative annulation under metal- and base-free conditions. Besides arylacetaldehydes, aliphatic aldehydes were also compatible with this system to deliver the alkyl-substituted imidazo[1,2-a]pyridines in excellent yields with the capability of gram-scale synthesis.
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000435352300003
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42609]
专题	中国科学院化学研究所
通讯作者	Huang, Huawen; Deng, Guo-Jun
作者单位	1.Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Tan, Jing,Ni, Penghui,Huang, Huawen,et al. Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2018,16(23):4227-4230.
APA	Tan, Jing,Ni, Penghui,Huang, Huawen,&Deng, Guo-Jun.(2018).Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes.ORGANIC & BIOMOLECULAR CHEMISTRY,16(23),4227-4230.
MLA	Tan, Jing,et al."Metal- and base-free synthesis of imidazo[1,2-a]pyridines through elemental sulfur-initiated oxidative annulation of 2-aminopyridines and aldehydes".ORGANIC & BIOMOLECULAR CHEMISTRY 16.23(2018):4227-4230.