Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine

doi:10.1016/j.snb.2018.05.057

CORC > 化学研究所 > 中国科学院化学研究所

	Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine
	Wu, Yehui 1; Chen, Yuzhi 1; Li, Yawen 1; Huang, Jia 3; Yu, Hao 1; Wang, Zhuo 1,2
刊名	SENSORS AND ACTUATORS B-CHEMICAL
	2018-10-01
卷号	270 页码:443-451
关键词	Nanozyme Gold Nanoparticle Peroxidase Purine Red Blood Cell
ISSN号	0925-4005
DOI	10.1016/j.snb.2018.05.057
英文摘要	Gold nanoparticles (AuNPs) is an important kind of nanozymes and a variety of its artificial enzymatic activities have been reported, such as oxidase, peroxidase, and superoxide dismutase. The DNA with poly purine-modified AuNPs shows an enhancement peroxidase activity compared with poly pyrimidine-modified AuNPs. In this work, purine derivatives are modified on the surface of AuNPs. The peroxidase-like activity of AuNPs is dependent on the chemical structure of the molecules capped on the surface. We find that ferric ions can accelerate the mimic enzymatic ability of 2, 6-diaminopurine (DAP) modified AuNPs. The enhanced catalytic activity comes from the synergistic reaction of AuNPs and ferric ions. The cooperative system can be applied to measure hemoglobin and red blood cells in urine with better sensitivity. Generally, there is no or few red blood cells in human urine. The presence of blood in the urine is closely related with serious diseases, for example chronic nephrotic syndrome and urinary system tumors. Compared the commercial urine test paper, the method based on DAP-AuNPs has a good sensitivity and wider quantitative range and will be helpful to do urine test at home.
语种	英语
出版者	ELSEVIER SCIENCE SA
WOS记录号	WOS:000434011500053
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42581]
专题	中国科学院化学研究所
通讯作者	Wang, Zhuo
作者单位	1.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Coll Sci, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China 3.China Japan Friendship Hosp, Dept Hepatobiliary Surg, Dept Gastroenterol, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Wu, Yehui,Chen, Yuzhi,Li, Yawen,et al. Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018,270:443-451.
APA	Wu, Yehui,Chen, Yuzhi,Li, Yawen,Huang, Jia,Yu, Hao,&Wang, Zhuo.(2018).Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine.SENSORS AND ACTUATORS B-CHEMICAL,270,443-451.
MLA	Wu, Yehui,et al."Accelerating peroxidase-like activity of gold nanozymes using purine derivatives and its application for monitoring of occult blood in urine".SENSORS AND ACTUATORS B-CHEMICAL 270(2018):443-451.