Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release

doi:10.1002/cphc.201800095

CORC > 化学研究所 > 中国科学院化学研究所

	Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release
	Hao, Yuwei 1,4; Li, Yingying 1; Zhang, Feilong 1,4; Cui, Haijun 2,4; Hu, Jinsong 3,4; Meng, Jingxin 2; Wang, Shutao 2,4
刊名	CHEMPHYSCHEM
	2018-08-17
卷号	19 期号:16 页码:2046-2051
关键词	Cell Capture And Release Electrochemical Responsive Materials Nonspecific Adhesion Smart Surfaces Thiophene Derivatives
ISSN号	1439-4235
DOI	10.1002/cphc.201800095
英文摘要	Highly efficient cell capture and release with low background are urgently required for early diagnosis of diseases such as cancer. Herein, we report an electrochemical responsive superhydrophilic surface exhibiting specific cell capture and release with high yields and extremely low nonspecific adhesion. Through electrochemical deposition, 3-substituted thiophene derivatives are deposited onto indium tin oxide (ITO) nanowire arrays with 4-n-nonylbenzeneboronic acid (BA) as dopant, fabricating the electrochemical responsive superhydrophilic surfaces. The molecular recognition between sialic acids over-expressed on the cell membrane and doped BAs endows the electrochemical responsive surfaces with the ability to capture and release targeted cancer cells. By adjusting the substituent group of thiophene derivatives, the surface wettability can be readily regulated and further utilized for reducing nonspecific cell adhesion. Significantly, the released cells still maintain a high proliferation ability, which indicates that the applied potential does not significantly harm the cells. Therefore, these results may provide a new strategy to achieve advanced functions of biomedical materials, such as low nonspecific adhesion.
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000441875500014
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/42337]
专题	中国科学院化学研究所
通讯作者	Meng, Jingxin; Wang, Shutao
作者单位	1.Chinese Acad Sci, BNLMS, Key Lab Green Printing, Inst Chem, Zhongguancun North First St 2, Beijing 100190, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Nanosci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Tech Inst Phys & Chem, Zhongguancun East Rd 29, Beijing 100190, Peoples R China 3.Chinese Acad Sci, BNLMS, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Zhongguancun North First St 2, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hao, Yuwei,Li, Yingying,Zhang, Feilong,et al. Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release[J]. CHEMPHYSCHEM,2018,19(16):2046-2051.
APA	Hao, Yuwei.,Li, Yingying.,Zhang, Feilong.,Cui, Haijun.,Hu, Jinsong.,...&Wang, Shutao.(2018).Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release.CHEMPHYSCHEM,19(16),2046-2051.
MLA	Hao, Yuwei,et al."Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release".CHEMPHYSCHEM 19.16(2018):2046-2051.