Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation

doi:10.1016/j.biortech.2018.03.070

	Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation
	Cao, Weifeng; Wang, Yujue; Luo, Jianquan; Yin, Junxiang; Wan, Yinhua
	2018
会议日期	OCT 23-25, 2017
会议地点	Daegu, SOUTH KOREA
关键词	alpha, omega-Dodecanedioic acid CHAIN DICARBOXYLIC-ACIDS Hydrolysate of Candida cells WASTE-WATER Candida viswanathii VISWANATHII alpha, omega-Dicarboxylic acids MECHANISMS Membrane bioreactor FILTRATION MUTANTS ALKANES SYSTEM PH
卷号	260
DOI	10.1016/j.biortech.2018.03.070
页码	9 ; 15
英文摘要	The aim of the present study is to develop an effective production process for a, omega-dodecanedioic acid (DC12) biosynthesis using n-dodecane and hydrolysate of Candida cells as substrates by membrane integrated repeated batch fermentation. Cells and n-dodecane were simultaneously recycled during the filtration of fermentation broth (FB) with a 150 kDa ceramic membrane under a cross-flow velocity of 4 m/s and a trans-membrane pressure of 0.2 MPa, and it was also revealed that the cells in the broth could alleviate the membrane fouling during the FB filtration. Moreover, the hydrolysate of the collected cells could be successfully used as a nitrogen source to replace 50% yeast extract for decreasing the DC12 production cost. With repeated-batch culture in a membrane bioreactor, the maximal DC12 productivity could be enhanced by 57.8% compared with the batch culture, meanwhile n-dodecane and cells could be recovered and used for the next fermentation cycle.
会议录	Article; Proceedings Paper
WOS记录号	WOS:000430969800002
内容类型	会议论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28942]
专题	中国科学院过程工程研究所
推荐引用方式 GB/T 7714	Cao, Weifeng,Wang, Yujue,Luo, Jianquan,et al. Improving alpha, omega-dodecanedioic acid productivity from n-dodecane and hydrolysate of Candida cells by membrane integrated repeated batch fermentation[C]. 见:. Daegu, SOUTH KOREA. OCT 23-25, 2017.