A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions

doi:10.1016/j.colsurfa.2019.04.020

	A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions
	Yang, Mengyao 1,2; Xing, Ruirui 1; Shen, Guizhi 1; Yuan, Chengqian 1; Yan, Xuehai 1,2
刊名	COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
	2019-07-05
卷号	572 页码:259-265
关键词	Cyclic dipeptide Self-assembly Hydrogel Stability Rheology
ISSN号	0927-7757
DOI	10.1016/j.colsurfa.2019.04.020
英文摘要	Peptide-based supramolecular hydrogels as functional soft materials hold great promising for biomedical applications. However, much effort has been devoted to the finding and development of linear peptide hydrogelators and related hydrogel materials. Usually, linear peptide hydrogels are subject to the environmental variations and suffer from rapid enzymatic degradation in physiological conditions, limiting their more broad range of applications. Herein, we discover that a cyclic dipeptide (Cyclo-(Leu-Phe), CLF) can serve as a versatile hydrogelator for formation of supramolecular hydrogels at various physiological and harsh environments including the presence of salts, proteins and enzymes as well as acidic and basic aqueous solutions. Importantly, the CLF hydrogels show robust stability and excellent rheological properties at the various conditions, which are attributable to the rigid molecular structure of cyclic dipeptides and their strong 3-dimentional intermolecular hydrogen bonding networks. Hence, cyclic dipeptides provide a new alternative for development of peptide-based hydrogel materials with properties and functions more adapted for the complex and harsh environments.
资助项目	National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21603233] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	MOLECULAR-WEIGHT GELATORS ; BONDING NETWORK ; PEPTIDE ; TRANSFORMATION ; TRANSITION ; TOUGH ; ACID
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000466612900028
资助机构	National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/28145]
专题	中国科学院过程工程研究所
通讯作者	Yan, Xuehai
作者单位	1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yang, Mengyao,Xing, Ruirui,Shen, Guizhi,et al. A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2019,572:259-265.
APA	Yang, Mengyao,Xing, Ruirui,Shen, Guizhi,Yuan, Chengqian,&Yan, Xuehai.(2019).A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,572,259-265.
MLA	Yang, Mengyao,et al."A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 572(2019):259-265.