Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy
	Yu, Xue-Feng; Qu, Guangbo; Wang, Jiahong; Zhou, Wenhua; Yang, Na; Gao, Jie; Chen, Tianfeng; Chu, Paul K.; He, Lizhen; Huang, Hao
刊名	BIOMATERIALS
	2018-07-01
卷号	171 页码:12-22
关键词	Black phosphorus 2D Layered materials Radiotherapy Photodynamic effect Cancer therapy
ISSN号	0142-9612
文献子类	Article
英文摘要	X-ray induced photodynamic therapy (X-ray-PDT) is a promising approach for synergistic cancer radiotherapy and development of suitable radiosensitizers is highly desired. In this paper, we propose black phosphorus/Bi2O3 (BP/Bi2O3) heterostructures as efficient and biocompatible radiosensitizers for synergistic cancer radiotherapy. The heterostructures are synthesized by growth of ultrasmall Bi2O3 nanoparticles onto BP nanosheets. The Bi2O3 decoration inhibits the rapid degradation of BP nanosheets by occupation of the defect sites, and the synergistic effects of BP and Bi2O3 enable O-1(2) overproduction under X-ray irradiation. This X-ray-PDT effect of the BP/Bi2O3 nanosheets enhances the radiotherapy activity towards cancer cells by inducing cell apoptosis and cycle arrest. In vivo treatment of melanoma conducted on a clinical radiotherapeutic instrument demonstrates that the BP/Bi2O3 sensitized radio-therapy inhibits tumor growth efficiently. Furthermore, the BP/Bi2O3 nanosheets composed of biological friendly P, O, and Bi elements shows good biocompatibility in vitro and in vivo. This radiosensitizer thus has immense clinical potential for cancer therapy, and our findings reveal a general strategy to fabricate stable BP-based heterostructures for different applications. (C) 2018 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/41048]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Yu, Xue-Feng,Qu, Guangbo,Wang, Jiahong,et al. Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy[J]. BIOMATERIALS,2018,171:12-22.
APA	Yu, Xue-Feng.,Qu, Guangbo.,Wang, Jiahong.,Zhou, Wenhua.,Yang, Na.,...&Huang, Hao.(2018).Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy.BIOMATERIALS,171,12-22.
MLA	Yu, Xue-Feng,et al."Stable black phosphorus/Bi2O3 heterostructures for synergistic cancer radiotherapy".BIOMATERIALS 171(2018):12-22.