Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure
	Su, Ruijun; Jin, Xiaoting; Xue, Bin; Zhou, Qunfang; Li, Zhuoyu
刊名	JOURNAL OF TOXICOLOGICAL SCIENCES
	2018
卷号	43 期号:2019-01-03 页码:101-111
关键词	Particular matter (PM2.5) Mitochondria ROS Bronchial epithelial cells Apoptosis
ISSN号	0388-1350
文献子类	Article
英文摘要	Mitochondria can be used as important biomarkers of pollutants on human health, and fine particulate matter (PM2.5) has been documented to cause respiratory damage. However, current studies about the relationship between PM2.5 and mitochondria in respiratory tract are limited and warrant further detailed investigations. Hence, the study was aimed to evaluate effects of PM2.5 on mitochondrial structure, investigate the link between PM2.5-induced mitochondrial disorder and respiratory damage, and delineate the possible mechanisms using both in vitro and in vivo models. PM2.5 exposure resulted in damage of mitochondrial structure, including mitochondrial dynamic, DNA biogenesis and morphological alteration 16HBE cells. Furthermore, PM(2.5)elevated ROS formation. However, DPI and NAC (inhibitor of ROS) in supplement restored PM2.5-induced mitochondrial disorder. PM,,also contributed to the 16HBE cells apoptosis via mitochondrial pathway. Additionally, the results coincided with the in vivo data which were obtained from bronchial tissues of SD rats exposed to PM2.5 for 30 days. Collectively, this study uncovers that PM2.5 leads to the disorder of mitochondrial structure via ROS generation, and then results in respiratory damage. It provides further understanding about the detrimental effect of PM on respiratory damage, and reveals a mechanistic basis for preventing outcomes in polluted environments.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/40984]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Su, Ruijun,Jin, Xiaoting,Xue, Bin,et al. Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure[J]. JOURNAL OF TOXICOLOGICAL SCIENCES,2018,43(2019-01-03):101-111.
APA	Su, Ruijun,Jin, Xiaoting,Xue, Bin,Zhou, Qunfang,&Li, Zhuoyu.(2018).Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure.JOURNAL OF TOXICOLOGICAL SCIENCES,43(2019-01-03),101-111.
MLA	Su, Ruijun,et al."Mitochondrial damage mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure".JOURNAL OF TOXICOLOGICAL SCIENCES 43.2019-01-03(2018):101-111.