Design and synthesis of selenazole-substituted ritonavir analogs

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Design and synthesis of selenazole-substituted ritonavir analogs
	Liu, Jun; Zhao, Chuanfang; Qiao, Junfei; Du, Yuguo
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2018-08-01
卷号	28 期号:14 页码:2379-2381
关键词	Selenazole Ritonavir Antiviral Protease inhibitor One-pot reaction
ISSN号	0960-894X
文献子类	Article
英文摘要	With the help of Surflex-Dock calculation, two ritonavir analogs in which one thioazole unit was replaced by selenazole have been designed and synthesized. The key selenazole structure was constructed from beta-azido diselenide through a cascade diselenide cleavage/selenocarbonylation/Staudinger reduction/aza-Wittig reaction and a following MnO2 oxidation. The accordingly prepared compounds exhibited good anti-HIV-1 (IIIB) activities comparable to that of the original ritonavir, as well as the positive SI values.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/40912]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Liu, Jun,Zhao, Chuanfang,Qiao, Junfei,et al. Design and synthesis of selenazole-substituted ritonavir analogs[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018,28(14):2379-2381.
APA	Liu, Jun,Zhao, Chuanfang,Qiao, Junfei,&Du, Yuguo.(2018).Design and synthesis of selenazole-substituted ritonavir analogs.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,28(14),2379-2381.
MLA	Liu, Jun,et al."Design and synthesis of selenazole-substituted ritonavir analogs".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28.14(2018):2379-2381.