Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis
	Zhu, Min; Chen, Xiao-Ying; Li, Yuan-Yuan; Yin, Nuo-Ya; Faiola, Francesco; Qin, Zhan-Fen; Wei, Wu-Ji
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2018-02-06
卷号	52 期号:3 页码:1602-1611
ISSN号	0013-936X
文献子类	Article
英文摘要	The safety of bisphenol A (BPA) alternatives has attracted much attention due to their wide use. In this study, we investigated the effects of bisphenol F (BPF), an alternative to BPA, on thyroid hormone (TH) signaling and postembryonic development in vertebrates using T3-induced and spontaneous Xenopus metamorphosis as models. We found that in the T3-induced metamorphosis assay, higher concentrations of BPF (100-10000 nM) antagonized T3-induced TH-response gene transcription and morphological changes including intestinal remodeling in a concentration-dependent manner, whereas 10 nM BPF exerted stimulatory effects on T3-induced integral metamorphosis when inhibited T3-induced TH-response gene transcription, demonstrating TH signaling disrupting effects of BPF. In the spontaneous metamorphosis assay, correspondingly, BPF inhibited development at metamorphic climax (with high endogenous TH levels), but promoted pre- and pro-metamorphic development (with low endogenous TH levels), displaying a developmental stage-dependent manner. Importantly, we observed agonistic actions of BPF on Notch signaling in intestines, showing that BPF disrupts vertebrate development possibly via multi pathways besides TH signaling. Thus, we infer the biphasic concentration-response relationship between BPF exposure and T3-induced metamorphosis could result from the interactions of TH signaling with other signaling pathways such as Notch signaling. Our study highlights the adverse influences of BPF on vertebrate development.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/40890]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Min,Chen, Xiao-Ying,Li, Yuan-Yuan,et al. Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(3):1602-1611.
APA	Zhu, Min.,Chen, Xiao-Ying.,Li, Yuan-Yuan.,Yin, Nuo-Ya.,Faiola, Francesco.,...&Wei, Wu-Ji.(2018).Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis.ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(3),1602-1611.
MLA	Zhu, Min,et al."Bisphenol F Disrupts Thyroid Hormone Signaling and Postembryonic Development in Xenopus laevis".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.3(2018):1602-1611.