Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China
	Ye, Li; Qiu, Shixin; Li, Xinhai; Jiang, Yuxuan; Jing, Chuanyong
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2018-11-01
卷号	640 页码:1-8
关键词	Antimony Biomarker Dietary exposure Methylated Sb
ISSN号	0048-9697
文献子类	Article
英文摘要	Antimony (Sb) exposure threatens human health. To identify human biomarkers for Sb exposure, we analyzed 480 environmental samples from an active Sb mining area in Hunan, China. Elevated Sb concentrations exceeding the reference level were detected in drinking water (70% of n = 83 total samples), foods (80%, n = 188), urine (95%, n = 63), saliva (44%, n = 48), hair (80%, n = 51) and nails (83%, n = 47). Drinking water contributed 85%-100% of the average daily dose (ADD) of Sb, and the total ADD (11.7 mu g/kg bodyweight/day) was up to thirty times higher than the oral reference dose (0.4 mu g/kg bodyweight/day) as recommended by USEPA. A positive correlation was found between ADD and Sb content in hair (p=0.02), but not in urine (p=0.051), saliva (p=0.52) or nails (p=0.85), suggesting that hair is the best non-invasive biomarker. Micro X-ray fluorescence analysis indicated that Sb is distributed in discrete spots in hair and nails, and Sb distribution is correlated with other metals. Methylated Sb species were predominant in urine (46%-100%) and saliva (74%-100%) in collected samples, implying that the human metabolic system adopts methylation as an effective pathway to detoxify and excrete Sb. (C) 2018 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/40879]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Ye, Li,Qiu, Shixin,Li, Xinhai,et al. Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2018,640:1-8.
APA	Ye, Li,Qiu, Shixin,Li, Xinhai,Jiang, Yuxuan,&Jing, Chuanyong.(2018).Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China.SCIENCE OF THE TOTAL ENVIRONMENT,640,1-8.
MLA	Ye, Li,et al."Antimony exposure and speciation in human biomarkers near an active mining area in Hunan, China".SCIENCE OF THE TOTAL ENVIRONMENT 640(2018):1-8.