20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment

doi:10.3390/md16110440

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	20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment
	Li, Xiao-Dong1 ; Li, Xin1,2,3 ; Li, Xiao-Ming 1,2,3; Xu, Gang-Ming 1,3; Liu, Yang1 ; Wang, Bin-Gui1,2,3
刊名	MARINE DRUGS
	2018-11-01
卷号	16 期号:11 页码:10
关键词	sediment-derived fungus Aspergillus wentii 20-nor-isopimarane epimers antimicrobial activity
ISSN号	1660-3397
DOI	10.3390/md16110440
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要	Four new uncommon 20-nor-isopimarane diterpenoid epimers, aspewentins I-L (1-4), together with a new methylated derivative of 3, aspewentin M (5), were isolated from the deep sea sediment-derived fungus Aspergillus wentii SD-310. The very similar structures of these epimers made the separation and purification procedures difficult. The structures of compounds 1-5 were illustrated based on spectroscopic analysis, and the absolute configurations of compounds 1-5 were unambiguously determined by the combination of NOESY, time-dependent density functional (TDDFT)-ECD calculations, and X-ray crystallographic analysis. These metabolites represented the rare examples of 20-nor-isopimarane analogues possessing a cyclohexa-2,5-dien-1-one moiety. These compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria, as well as plant-pathogenic fungi. While compounds 1 and 2 exhibited inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio harveyi, and V. parahaemolyticus, compound 5 showed potent activity against the plant pathogen Fusarium graminearum.
资助项目	National Key R&D Program of China[2018YFC0310800] ; National Natural Science Foundation of China[31700043] ; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14]
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MDPI
WOS记录号	WOS:000451159500043
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/156103]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-Dong,Li, Xin,Li, Xiao-Ming,et al. 20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment[J]. MARINE DRUGS,2018,16(11):10.
APA	Li, Xiao-Dong,Li, Xin,Li, Xiao-Ming,Xu, Gang-Ming,Liu, Yang,&Wang, Bin-Gui.(2018).20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment.MARINE DRUGS,16(11),10.
MLA	Li, Xiao-Dong,et al."20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment".MARINE DRUGS 16.11(2018):10.