Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet's Qamdo City, China

doi:10.1038/s41598-019-39792-0

	Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet's Qamdo City, China
	Zha, Xinjie 1,2; Gao, Xing 1
刊名	SCIENTIFIC REPORTS
	2019-02-21
卷号	9 页码:8
ISSN号	2045-2322
DOI	10.1038/s41598-019-39792-0
通讯作者	Gao, Xing(gxing@igsnrr.ac.cn)
英文摘要	We studied Tibet's Qamdo City, which currently hosts the most serious prevalence of Kashin-Beck osteoarthropathy (KB) in China. This study utilizes the geographical detector (GeoDetector) algorithm to measure the individual and interactive influences of risk factors on KB and to quantify the highest potential risk subzones of each principal factor. With a comprehensive consideration of 13 possible related factors, namely, the tectonic division, stratum, moisture index, gross domestic product, mean annual precipitation, soil type, groundwater type, elevation, mean annual temperature, vegetation type, geomorphic type, slope degree and slope aspect, our results indicate that the main exposure factors for KB in Qamdo City are geological factors (tectonic division and stratum), wetting factors (moisture index and mean annual precipitation), and an economic factor (gross domestic product). In contrast, other factors have little effect on the prevalence of KB in Qamdo City. All 13 factors either nonlinearly or bivariately enhance each other, and the interactions between these factors can increase the prevalence of KB. Consequently, it can be inferred that KB in Qamdo City is caused primarily by a set of multiple and interrelated disease risk factors.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA19040305] ; Foundation of the State Key Laboratory of Resources and Environmental Information System[O88RAA0BYA] ; Scientific Research Project of Tibet Autonomous Region[XZ201801NA02]
WOS关键词	FUNGAL CONTAMINATION ; DRINKING-WATER ; DISEASE ; SELENIUM ; HEALTH ; IODINE ; SOIL ; DEFICIENCY ; DEFECTS ; FINLAND
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000459281500040
资助机构	Strategic Priority Research Program of the Chinese Academy of Sciences ; Foundation of the State Key Laboratory of Resources and Environmental Information System ; Scientific Research Project of Tibet Autonomous Region
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/49473]
专题	中国科学院地理科学与资源研究所
通讯作者	Gao, Xing
作者单位	1.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zha, Xinjie,Gao, Xing. Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet's Qamdo City, China[J]. SCIENTIFIC REPORTS,2019,9:8.
APA	Zha, Xinjie,&Gao, Xing.(2019).Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet's Qamdo City, China.SCIENTIFIC REPORTS,9,8.
MLA	Zha, Xinjie,et al."Ecological analysis of Kashin-Beck osteoarthropathy risk factors in Tibet's Qamdo City, China".SCIENTIFIC REPORTS 9(2019):8.