A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer’s disease | |
Li-Li Kong1,3; Rui Bi1; Yong-Gang Yao1,2,4; Rongcan Luo1,4; Yong Wu1,4; Min Xu1,4; Hejiang Zhou1 | |
刊名 | Alzheimer's & Dementia |
2018 | |
期号 | 14页码:215-229 |
关键词 | Alzheimer’s Disease Differential Expression Convergent Functional Genomic Upstream Regulator Database |
DOI | 10.1016/j.jalz.2017.08.012 |
英文摘要 | Introduction: Profiling the spatial-temporal expression pattern and characterizing the regulatory net-works of brain tissues are vital for understanding the pathophysiology of Alzheimer’s disease (AD).Methods: We performed a systematic integrated analysis of expression profiles of AD-affected braintissues(684ADand562controls).Anetwork-basedconvergentfunctionalgenomicapproachwasusedto prioritize possible regulator genes during AD development, followed by functional characterization.Results: We generated a complete list of differentially expressed genes and hub genes of the tran-scriptomic network in AD brain and constructed a Web server (www.alzdata.org) for public access.Seventeen hub genes active at the early stages, especially YAP1, were recognized as upstream regu-lators of the AD network. Cellular assays proved that early alteration of YAP1 could promote AD byinfluencing the whole transcriptional network.Discussion: Early expression disturbance of hub genes is an important feature of AD development,and interfering with this process may reverse the disease progression. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://159.226.149.26:8080/handle/152453/12368] |
专题 | 昆明动物研究所_重大疾病机理的遗传学 |
通讯作者 | Rongcan Luo |
作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China 3.Institute of Health Science, Anhui University, Hefei, Anhui, China 4.unming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China |
推荐引用方式 GB/T 7714 | Li-Li Kong,Rui Bi,Yong-Gang Yao,et al. A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer’s disease[J]. Alzheimer's & Dementia,2018(14):215-229. |
APA | Li-Li Kong.,Rui Bi.,Yong-Gang Yao.,Rongcan Luo.,Yong Wu.,...&Hejiang Zhou.(2018).A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer’s disease.Alzheimer's & Dementia(14),215-229. |
MLA | Li-Li Kong,et al."A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer’s disease".Alzheimer's & Dementia .14(2018):215-229. |
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