Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina).

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	Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina).
	zhengyt@mail.kiz.ac.cn ; Zhang XH 1,2; Lian XD 1,2; Dai ZX 2; Zheng YT*2,3
刊名	Infection, Genetics and Evolution
	2017
卷号	期号:页码:Accepted
关键词	Aids Model Mhc Class Ii Macaca Leonina Northern Pig-tailed Macaque
英文摘要	The northern pig-tailed macaque (Macaca leonina) has been identified as an independent species from the pig-tailed macaque group. The species is a promising animal model for HIV/AIDS pathogenesis and vaccine studies due to susceptibility to HIV-1. However, the major histocompatibility complex (MHC) genetics in northern pig-tailed macaques remains poorly understood. We have previously studied the MHC class I genes in northern pig-tailed macaques and identified 39 novel alleles. Here, we describe the MHC class II alleles in all six classical loci (DPA, DPB, DQA, DQB, DRA, and DRB) from northern pig-tailed macaques using a sequence-based typing method for the first time. A total of 60 MHC-II alleles were identified of which 27 were shared by other macaque species. Additionally, northern pig-tailed macaques expressed a single DRA and multiple DRB genes similar to the expression in humans and other macaque species. Polymorphism and positive selection were detected, and phylogenetic analysis suggested the presence of a common ancestor in human and northern pig-tailed macaque MHC class II allelic lineages at the DQA, DQB, and DRB loci. The characterization of full-length MHC class II alleles in this study significantly improves understanding of the immunogenetics of northern pig-tailed macaques and provides the groundwork for future animal model studies.
语种	英语
资助机构	This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). ; This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). ; This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), Natural Science Foundation of Yunnan Province (2014FB181, P0120150150). ; This work was supported by the Key Scientific and Technological Program of China (2017ZX10304402-002), the National Basic Research Program of China (2012CBA01305), the National Natural Science Foundation of China (81373124, 81671627, 81172876, 81471620, 81571606), the Knowledge Innovation Program of CAS (ZDRW-ZS-2016-4-2), Natural Science Foundation of Yunnan Province (2014FB181, P0120150150).
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/12085]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_分子免疫药理学昆明动物研究所_中国科学院昆明灵长类研究中心
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.University of Chinese Academy of Sciences, Beijing 100049, China. 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
推荐引用方式 GB/T 7714	zhengyt@mail.kiz.ac.cn,Zhang XH,Lian XD,et al. Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina).[J]. Infection, Genetics and Evolution,2017,():Accepted.
APA	zhengyt@mail.kiz.ac.cn,Zhang XH,Lian XD,Dai ZX,&Zheng YT.(2017).Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina)..Infection, Genetics and Evolution,(*),Accepted.
MLA	zhengyt@mail.kiz.ac.cn,et al."Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina).".Infection, Genetics and Evolution .(2017):Accepted.