Predict disease progression from T cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室

	Predict disease progression from T cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection
	Song TZ 1,4; zhengyt@mail.kiz.ac.cn ; Chen M 1,4; Song JH 1,3; Jiang J 1,4; Zheng YT*1,2; Pang W 1; Tian RR 1; Lian XD 1,4; Xiao Y 1
刊名	Immunology
	2017
卷号	期号:页码:piblished online
关键词	Macaca Leonina Sivmac239 t Cell Phenotype Disease Progression Northern Pig-tailed Macaques
英文摘要	Macaca leonina (northern pig-tailed macaques, NPMs) have variable disease progression during SIVmac239 infection. In the present study, we analyzed, for the first time, the correlations between T cell phenotypes and disease progression in NPMs during SIVmac239 infection. In comparison to normal progressors (NPs), slow progressors (SPs) had lower chronic T cell activation and exhaustion levels. In addition, SPs showed higher peripheral CD4+ T cell count, CD4/CD8 ratio and lower plasma viral load than NPs. CD4+ T cell count and CD4/CD8 ratio decreased more sharply in NPs than in SPs. Furthermore, T cells in NPs were higher differentiated, at least in acute infection, than in SPs. These results indicated that T cell phenotypes were correlated with disease progression in SIVmac239-infected NPMs and these correlations may provide valuable guidance for the improvement of therapeutic strategies tested in NPMs.
语种	英语
资助机构	This work was partly supported by grand from the National Natural Science Foundation of China (81471620; 81671627; 81571606; U1604287; 81601808; 81172876; U0832601), the National Basic Research Program of China (2012CBA01305), and the Knowledge Innovation Program of the Chinese Academy of Sciences (CASIMM0320163020; KSCX2-EW-R-13), and Yunnan Applicative and Basic Research Program (2014FB181; 201501PH00015; C0120150617). ; This work was partly supported by grand from the National Natural Science Foundation of China (81471620; 81671627; 81571606; U1604287; 81601808; 81172876; U0832601), the National Basic Research Program of China (2012CBA01305), and the Knowledge Innovation Program of the Chinese Academy of Sciences (CASIMM0320163020; KSCX2-EW-R-13), and Yunnan Applicative and Basic Research Program (2014FB181; 201501PH00015; C0120150617). ; This work was partly supported by grand from the National Natural Science Foundation of China (81471620; 81671627; 81571606; U1604287; 81601808; 81172876; U0832601), the National Basic Research Program of China (2012CBA01305), and the Knowledge Innovation Program of the Chinese Academy of Sciences (CASIMM0320163020; KSCX2-EW-R-13), and Yunnan Applicative and Basic Research Program (2014FB181; 201501PH00015; C0120150617). ; This work was partly supported by grand from the National Natural Science Foundation of China (81471620; 81671627; 81571606; U1604287; 81601808; 81172876; U0832601), the National Basic Research Program of China (2012CBA01305), and the Knowledge Innovation Program of the Chinese Academy of Sciences (CASIMM0320163020; KSCX2-EW-R-13), and Yunnan Applicative and Basic Research Program (2014FB181; 201501PH00015; C0120150617).
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11894]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_分子免疫药理学昆明动物研究所_中国科学院昆明灵长类研究中心
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Institute of Health Sciences, Anhui University, Hefei, Anhui 230601, China 4.University of Chinese Academy of Sciences, Beijing 100091, China
推荐引用方式 GB/T 7714	Song TZ,zhengyt@mail.kiz.ac.cn,Chen M,et al. Predict disease progression from T cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection[J]. Immunology,2017,():piblished online.
APA	Song TZ.,zhengyt@mail.kiz.ac.cn.,Chen M.,Song JH.,Jiang J.,...&Zhang MX.(2017).Predict disease progression from T cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection.Immunology,(),piblished online.
MLA	Song TZ,et al."Predict disease progression from T cell phenotypes in northern pig-tailed macaques (Macaca leonina) during SIVmac239 infection".Immunology .(2017):piblished online.