Analysis of the genetic variation in mitochondrial DNA, Y-chromosome sequences, and MC1R sheds light on the ancestry of Nigerian indigenous pigs

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室

	Analysis of the genetic variation in mitochondrial DNA, Y-chromosome sequences, and MC1R sheds light on the ancestry of Nigerian indigenous pigs
	Frantz L 6,11; Murphy RW 5,8; Xie HB 7,8; Peng MS7,8,10; Zhang YP7,8,9,10; Olorungbounmi TO 4; Boladuro B 4; Adeola AC 7,8; Oluwole OO 4; Olaogun SC 3
刊名	Genetics Selection Evolution
	2017
卷号	49 期号:X 页码:e52
其他题名	pengminsheng@mail.kiz.ac.cn; zhangyp@mail.kiz.ac.cn
英文摘要	BACKGROUND: The history of pig populations in Africa remains controversial due to insufficient evidence from archaeological and genetic data. Previously, a Western ancestry for West African pigs was reported based on loci that are involved in the determination of coat color. We investigated the genetic diversity of Nigerian indigenous pigs (NIP) by simultaneously analyzing variation in mitochondrial DNA (mtDNA), Y-chromosome sequence and the melanocortin receptor 1 (MC1R) gene. RESULTS: Median-joining network analysis of mtDNA D-loop sequences from 201 NIP and previously characterized loci clustered NIP with populations from the West (Europe/North Africa) and East/Southeast Asia. Analysis of partial sequences of the Y-chromosome in 57 Nigerian boars clustered NIP into lineage HY1. Finally, analysis of MC1R in 90 NIP resulted in seven haplotypes, among which the European wild boar haplotype was carried by one individual and the European dominant black by most of the other individuals (93%). The five remaining unique haplotypes differed by a single synonymous substitution from European wild type, European dominant black and Asian dominant black haplotypes. CONCLUSIONS: Our results demonstrate a European and East/Southeast Asian ancestry for NIP. Analyses of MC1R provide further evidence. Additional genetic analyses and archaeological studies may provide further insights into the history of African pig breeds. Our findings provide a valuable resource for future studies on whole-genome analyses of African pigs.
语种	英语
资助机构	This work was sup‑ ported by the Sino‑Africa Joint Research Center, Chinese Academy of Sciences (SAJC201611 and SAJC201306) and the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences (the Large Research Infrastructure Funding). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to MSP. In addition, this work was also supported, in part, by the Chinese Academy of Sciences President’s Interna‑ tional Fellowship Initiative (2017VBA0003), and the manuscript preparation by a Natural Sciences and Engineering Research Council of Canada Discovery Grant A3148 to R.W.M. ; This work was sup‑ ported by the Sino‑Africa Joint Research Center, Chinese Academy of Sciences (SAJC201611 and SAJC201306) and the Animal Branch of the Germplasm Bank of Wild Species, Chinese Academy of Sciences (the Large Research Infrastructure Funding). The Youth Innovation Promotion Association, Chinese Academy of Sciences provided support to MSP. In addition, this work was also supported, in part, by the Chinese Academy of Sciences President’s Interna‑ tional Fellowship Initiative (2017VBA0003), and the manuscript preparation by a Natural Sciences and Engineering Research Council of Canada Discovery Grant A3148 to R.W.M.
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11770]
专题	昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_分子进化基因组学
作者单位	1.Department of Veterinary Surgery and Theriogenology, College of Veteri‑ nary Medicine, University of Agriculture Makurdi, Makurdi, Nigeria 2.Department of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria 3.State Key Laboratory for Conservation and Uti‑ lization of Bio‑Resources in Yunnan, Yunnan University, Kunming, China. 4.Institute of Agricul‑ tural Research and Training, Obafemi Awolowo University, Ibadan, Nigeria 5.School of Biological and Chemical Sciences, Queen Mary University of London, London, UK 6.The Palaeogenomics and Bio‑Archaeology Research Network, Research Laboratory for Archaeology, University of Oxford, Oxford, UK 7.Sino-Africa Joint Research Center, Chinese Academy of Sciences, Kunming, China 8.State Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 9.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 10.Centre for Biodiversity and Conservation Biology, Royal Ontario Museum, Toronto, Canada
推荐引用方式 GB/T 7714	Frantz L,Murphy RW,Xie HB,et al. Analysis of the genetic variation in mitochondrial DNA, Y-chromosome sequences, and MC1R sheds light on the ancestry of Nigerian indigenous pigs[J]. Genetics Selection Evolution,2017,49(X):e52.
APA	Frantz L.,Murphy RW.,Xie HB.,Peng MS.,Zhang YP.,...&Oladele BM.(2017).Analysis of the genetic variation in mitochondrial DNA, Y-chromosome sequences, and MC1R sheds light on the ancestry of Nigerian indigenous pigs.Genetics Selection Evolution,49(X),e52.
MLA	Frantz L,et al."Analysis of the genetic variation in mitochondrial DNA, Y-chromosome sequences, and MC1R sheds light on the ancestry of Nigerian indigenous pigs".Genetics Selection Evolution 49.X(2017):e52.