Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification

doi:10.1002/jssc.201500834

	Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification
	Zhao, Jianchao 1; Wu, Haixia 1; Wang, Dongqiang 1; Wu, Haibo 1; Cheng, Lingping 1; Jin, Yu 1; Ke, Yanxiong 1,2
刊名	JOURNAL OF SEPARATION SCIENCE
	2015-11-01
卷号	38 期号:22 页码:3884-3890
关键词	Amino Acids Chiral Selectors Cinchona Alkaloids Crown Ethers Enantioseparation
ISSN号	1615-9306
DOI	10.1002/jssc.201500834
文献子类	Article
英文摘要	To improve the chiral recognition capability of a cinchona alkaloid crown ether chiral stationary phase, the crown ether moiety was modified by the chiral group of (1S, 2S)-2-aminocyclohexyl phenylcarbamate. Both quinine and quinidine-based stationary phases were evaluated by chiral acids, chiral primary amines and amino acids. The quinine/quinidine and crown ether provided ion-exchange sites and complex interaction site for carboxyl group and primary amine group in amino acids, respectively, which were necessary for the chiral discrimination of amino acid enantiomers. The introduction of the chiral group greatly improved the chiral recognition for chiral primary amines. The structure of crown ether moiety was proved to play a dominant role in the chiral recognitions for chiral primary amines and amino acids.
WOS关键词	LIQUID-CHROMATOGRAPHIC RESOLUTION ; ZWITTERION-EXCHANGE MODES ; AMINO-ACIDS ; (+)-(18-CROWN-6)-2,3,11,12-TETRACARBOXYLIC ACID ; ENANTIOSEPARATION CHARACTERISTICS ; PSEUDO-18-CROWN-6 ETHER ; ENANTIOMER SEPARATION ; CYCLIC POLYETHERS ; MOBILE-PHASE ; METAL-SALTS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000365320800010
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171616]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ke, Yanxiong
作者单位	1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Jianchao,Wu, Haixia,Wang, Dongqiang,et al. Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification[J]. JOURNAL OF SEPARATION SCIENCE,2015,38(22):3884-3890.
APA	Zhao, Jianchao.,Wu, Haixia.,Wang, Dongqiang.,Wu, Haibo.,Cheng, Lingping.,...&Ke, Yanxiong.(2015).Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification.JOURNAL OF SEPARATION SCIENCE,38(22),3884-3890.
MLA	Zhao, Jianchao,et al."Improvement of chiral stationary phases based on cinchona alkaloids bonded to crown ethers by chiral modification".JOURNAL OF SEPARATION SCIENCE 38.22(2015):3884-3890.