Reevaluation of the stability of G-quadruplex structures under crowding conditions

doi:10.1016/j.biochi.2015.12.012

	Reevaluation of the stability of G-quadruplex structures under crowding conditions
	Zhou, Jun 3,4; Tateishi-Karimata, Hisae 5,6; Mergny, Jean-Louis 1,2; Cheng, Mingpan 3; Feng, Zhaochi 3; Miyoshi, Daisuke 5,6; Sugimoto, Naoki 5,6; Li, Can 3
刊名	BIOCHIMIE
	2016-02-01
卷号	121 页码:204-208
关键词	G-quadruplex Stability Molecular Crowding Hydration Divalent Cations
ISSN号	0300-9084
DOI	10.1016/j.biochi.2015.12.012
文献子类	Article
英文摘要	To evaluate the stability of G-quadruplex structures comprehensively, parallel (type I), antiparallel (type II), and hybrid (type III) G-quadruplexes in the presence of monovalent and divalent cations were assessed by UV-melting technique under dilute and crowded conditions. In the presence of monovalent cations, the stability of G-quadruplexes was increased by the presence of molecular crowding agents. Surprisingly, crowding agents stabilized parallel G-quadruplex, but had no effect on stability or destabilized antiparallel or hybrid G-quadruplex structures in the presence of divalent cations. A hydration study of the antiparallel G-quadruplex revealed that more water molecules are bound in the presence of divalent cations than with monovalent ions. These analyses under conditions that mimic those in cells further our understanding of how G-quadruplex structures are involved in biological processes. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
WOS关键词	INTRAMOLECULAR G-QUADRUPLEX ; HUMAN TELOMERIC SEQUENCE ; CIRCULAR-DICHROISM ; K+ SOLUTION ; NUCLEIC-ACIDS ; LOOP LENGTH ; DNA ; HYDRATION ; BINDING ; FORMS
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000369679700023
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171406]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhou, Jun; Li, Can
作者单位	1.Univ Bordeaux, F-33000 Bordeaux, France 2.INSERM, U869, IECB, F-33600 Pessac, France 3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 4.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China 5.Konan Univ, Dept Frontier Inst Biomol Engn Res FIBER, Chuo Ku, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan 6.Konan Univ, Grad Sch Frontiers Innovat Res Sci & Technol FIRS, Chuo Ku, 7-1-20 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan
推荐引用方式 GB/T 7714	Zhou, Jun,Tateishi-Karimata, Hisae,Mergny, Jean-Louis,et al. Reevaluation of the stability of G-quadruplex structures under crowding conditions[J]. BIOCHIMIE,2016,121:204-208.
APA	Zhou, Jun.,Tateishi-Karimata, Hisae.,Mergny, Jean-Louis.,Cheng, Mingpan.,Feng, Zhaochi.,...&Li, Can.(2016).Reevaluation of the stability of G-quadruplex structures under crowding conditions.BIOCHIMIE,121,204-208.
MLA	Zhou, Jun,et al."Reevaluation of the stability of G-quadruplex structures under crowding conditions".BIOCHIMIE 121(2016):204-208.