Serum Lipidomics Study of Polycystic Ovarian Syndrome Based on Liquid Chromatography-Mass Spectrometry

	Serum Lipidomics Study of Polycystic Ovarian Syndrome Based on Liquid Chromatography-Mass Spectrometry
	Yang Zhao-Peng 1; Xu Fang 2; Zhao Xin-Jie 1; Hou Li-Hui 2; Xu Guo-Wang 1
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2015-10-01
卷号	43 期号:10 页码:1445-1451
关键词	Polycystic Ovarian Syndrome Liquid Chromatography-mass Spectrometry Lipidomics Abnormal Lipid Metabolism
ISSN号	0253-3820
文献子类	Article
英文摘要	Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders in fertile women and contributes to female infertility. Polycystic ovarian syndrome is heterogeneous and its pathogenesis has not been clearly elucidated. In this study, sera from 74 PCOS patients and 54 healthy persons as control were analyzed based on reversed. phase high performance liquid chromatography coupled with quadrupole time. of. flight mass spectrometry (RPLC/Q-TOF-MS). A total of 314 lipid compounds of 15 classes were indentified. Non. parametric statistical test was performed on metabolomics data and p < 0.05 was considered as significant. Compared with normal women, the serum levels of unsaturated fatty acids, most sphingomyelins, diacylglycerol and triglyceridewere were elevated, while the levels of mostphosphatidylcholine, lyso. phosphatidylcholine, lyso. phosphatidylethanolamine were reduced in PCOS women. Furthermore, in obese PCOS women, the higher levels of unsaturated fatty acids, sphingomyelins, diacylglycerol and triglyceride, and the lower levels of most phosphatidylcholine and lyso. phosphatidylcholine were found. This study demonstrated that lipidomics is a powerful tool for disease classification.
WOS关键词	INDUCED INSULIN-RESISTANCE ; PATHOGENESIS ; OBESITY ; PCOS
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000371688100003
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/171042]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yang Zhao-Peng
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Gynaecol Clin, Haerbin 150040, Peoples R China
推荐引用方式 GB/T 7714	Yang Zhao-Peng,Xu Fang,Zhao Xin-Jie,et al. Serum Lipidomics Study of Polycystic Ovarian Syndrome Based on Liquid Chromatography-Mass Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2015,43(10):1445-1451.
APA	Yang Zhao-Peng,Xu Fang,Zhao Xin-Jie,Hou Li-Hui,&Xu Guo-Wang.(2015).Serum Lipidomics Study of Polycystic Ovarian Syndrome Based on Liquid Chromatography-Mass Spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,43(10),1445-1451.
MLA	Yang Zhao-Peng,et al."Serum Lipidomics Study of Polycystic Ovarian Syndrome Based on Liquid Chromatography-Mass Spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 43.10(2015):1445-1451.