Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model

doi:10.1039/c6ra05645h

	Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model
	Liu, Lilu 2; Xie, Zhaorong 2; Zhang, Wenyuan 2; Fang, Shimeng 2; Kong, Jing 2; Jin, Dong 2; Li, Jiao 2; Li, Xiaojie 2; Yang, Xuesong 3; Luo, Yong 1
刊名	RSC ADVANCES
	2016
卷号	6 期号:42 页码:35248-35256
ISSN号	2046-2069
DOI	10.1039/c6ra05645h
文献子类	Article
英文摘要	We developed a biomimetic microfluidic model to reproduce hallmark events of tumor-induced angiogenesis. The angiogenic capabilities of salivary gland adenoid cystic carcinoma (ACC) cells and oral squamous cell carcinoma (SCC) cells were assessed in this model. The traditional nude mouse xenograft model was used to investigate the physiological similarity of the microfluidic model to animal models, and the results showed that the angiogenic potential of ACC and SCC cells assessed by the microfluidic model was in agreement with the results obtained from the nude mouse model. The microfluidic model was subsequently used to evaluate the effect of antiangiogenic drugs on ACC- and SCC-induced angiogenesis. The antiangiogenic effect of anti-VEGF was further compared between the microfluidic and nude mouse models, and showed that it effectively inhibited tumor-induced angiogenesis in both the microfluidic model and the nude mouse model. Thus, tumor-induced angiogenesis reproduced in the microfluidic model may expand the capabilities of cell culture models, providing a low-cost, timesaving, and rapid alternative to animal models.
WOS关键词	ENDOTHELIAL GROWTH-FACTOR ; CELL-INTERACTIONS ; IN-VITRO ; CANCER ; EXPRESSION ; MORPHOGENESIS ; COCULTURE ; PHOSPHORYLATION ; ANGIOPOIETIN-2 ; MICROVESSELS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000374349600013
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170866]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Liu, Tingjiao
作者单位	1.Dalian Univ Technol, Fac Chem Environm & Biol Sci & Technol, 2 Linggong Rd, Dalian 116024, Peoples R China 2.Dalian Med Univ, Coll Stomatol, Sect Oral Pathol, West Sect 9,South Rd Lvshun, Dalian 116044, Peoples R China 3.Dalian Med Univ, Liaoning Prov Core Lab Glycobiol & Glycoengn, Dept Biochem & Mol Biol, Dalian, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, 457 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Liu, Lilu,Xie, Zhaorong,Zhang, Wenyuan,et al. Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model[J]. RSC ADVANCES,2016,6(42):35248-35256.
APA	Liu, Lilu.,Xie, Zhaorong.,Zhang, Wenyuan.,Fang, Shimeng.,Kong, Jing.,...&Liu, Tingjiao.(2016).Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model.RSC ADVANCES,6(42),35248-35256.
MLA	Liu, Lilu,et al."Biomimetic tumor-induced angiogenesis and anti-angiogenic therapy in a microfluidic model".RSC ADVANCES 6.42(2016):35248-35256.