Highly Catalytic Nanodots with Renal Clearance for Radiation Protection

doi:10.1021/acsnano.6b00321

	Highly Catalytic Nanodots with Renal Clearance for Radiation Protection
	Deng, Dehui 6; Zhang, Xiao-Dong 1; Zhang, Jinxuan 2; Wang, Junying 3,4; Yang, Jiang 5; Chen, Jie 3,4; Shen, Xiu 3,4; Deng, Jiao 6; Long, Wei 3,4; Sun, Yuan-Ming 3,4
刊名	ACS NANO
	2016-04-01
卷号	10 期号:4 页码:4511-4519
关键词	Radiation Radioprotectants Mos2 Dots
ISSN号	1936-0851
DOI	10.1021/acsnano.6b00321
文献子类	Article
英文摘要	Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 mn) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days.
WOS关键词	GUIDED PHOTOTHERMAL THERAPY ; CERIUM OXIDE NANOPARTICLES ; WALLED CARBON NANOTUBES ; IONIZING-RADIATION ; DRUG-DELIVERY ; NUCLEAR-POWER ; GOLD NANOPARTICLES ; CELLULAR-DAMAGE ; CANCER ; MOS2
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000375245000070
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170864]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhang, Xiao-Dong; Li, Meixian
作者单位	1.Tianjin Univ, Dept Phys, Sch Sci, Tianjin 300354, Peoples R China 2.Peking Univ, Inst Analyt Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 3.Chinese Acad Med Sci, Tianjin Key Lab Mol Nucl Med, Inst Radiat Med, 238 Baidi Rd, Tianjin 300192, Peoples R China 4.Peking Union Med Coll, 238 Baidi Rd, Tianjin 300192, Peoples R China 5.Fudan Univ, Dept Environm Sci & Engn, Environm Energy & Nat Resources Ctr, 220 Handan Rd, Shanghai 200433, Peoples R China 6.Chinese Acad Sci, Dalian Inst Chem Phys, iChEM, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Deng, Dehui,Zhang, Xiao-Dong,Zhang, Jinxuan,et al. Highly Catalytic Nanodots with Renal Clearance for Radiation Protection[J]. ACS NANO,2016,10(4):4511-4519.
APA	Deng, Dehui.,Zhang, Xiao-Dong.,Zhang, Jinxuan.,Wang, Junying.,Yang, Jiang.,...&Li, Meixian.(2016).Highly Catalytic Nanodots with Renal Clearance for Radiation Protection.ACS NANO,10(4),4511-4519.
MLA	Deng, Dehui,et al."Highly Catalytic Nanodots with Renal Clearance for Radiation Protection".ACS NANO 10.4(2016):4511-4519.