Metabonomic study of rats exposed to cigarette sidestream smoke

doi:10.1007/s11771-016-3100-6

	Metabonomic study of rats exposed to cigarette sidestream smoke
	Shi Xian-zhe 3; Luo Jia 2; Ren Feng-lian 1; Lian Wen-liu 1,2
刊名	JOURNAL OF CENTRAL SOUTH UNIVERSITY
	2016-03-01
卷号	23 期号:3 页码:535-543
关键词	Metabonomics Rats Urine Endogenous Metabolites Exogenous Metabolites
ISSN号	2095-2899
DOI	10.1007/s11771-016-3100-6
文献子类	Article
英文摘要	A metabonomic approach was undertaken in order to detect urinary endogenous and exogenous metabolites and to evaluate the effects of passive exposure to cigarette sidestream smoke on rats. Urinary samples from three groups of rats were determined including control rats, rats treated with blended cigarettes (nonmenthol cigarettes) and rats treated with menthol cigarettes. The total urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), total 1-hydroxypyrene (1-HOP) and 3-hydroxybenzo[a] pyrene (3-HOBaP) were determined for assessing exposure to cigarette sidestream smoke toxins. Urinary endogenous metabolites in the three groups of rats were also analyzed and the data were processed by chemometrics. Eleven endogenous metabolites were found and identified. Their relative levels were compared among the three groups. The results show that cigarette sidestream smoke has complex effect on rats. Blended cigarette group makes difference to menthol cigarette group in the rats' urinary metabolic changes. Menthol adding to cigarettes has positive and negative effects on rats, respectively. The urinary metabolic profiling of menthol cigarette group is closer to that of control group.
WOS关键词	POLYCYCLIC AROMATIC-HYDROCARBONS ; ENVIRONMENTAL TOBACCO-SMOKE ; LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; ADULT SMOKERS ; L-DOPA ; URINE ; BIOMARKERS ; CANCER ; OPPORTUNITIES
WOS研究方向	Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL OF CENTRAL SOUTH UNIV TECHNOLOGY
WOS记录号	WOS:000374405100006
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170768]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ren Feng-lian
作者单位	1.Cent S Univ, Sch Chem & Chem Engn, Changsha 410083, Peoples R China 2.China Tobacco Hunan Ind Co Ltd, Technol & Res Ctr, Changsha 410014, Hunan, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Shi Xian-zhe,Luo Jia,Ren Feng-lian,et al. Metabonomic study of rats exposed to cigarette sidestream smoke[J]. JOURNAL OF CENTRAL SOUTH UNIVERSITY,2016,23(3):535-543.
APA	Shi Xian-zhe,Luo Jia,Ren Feng-lian,&Lian Wen-liu.(2016).Metabonomic study of rats exposed to cigarette sidestream smoke.JOURNAL OF CENTRAL SOUTH UNIVERSITY,23(3),535-543.
MLA	Shi Xian-zhe,et al."Metabonomic study of rats exposed to cigarette sidestream smoke".JOURNAL OF CENTRAL SOUTH UNIVERSITY 23.3(2016):535-543.