Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography

doi:10.1002/jssc.201501157

	Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography
	Szwed, Kamila; Ou, Junjie; Huang, Guang; Lin, Hui; Liu, Zhongshan; Wang, Hongwei; Zou, Hanfa
刊名	JOURNAL OF SEPARATION SCIENCE
	2016-03-01
卷号	39 期号:6 页码:1110-1117
关键词	Capillary Liquid Chromatography Cyclodextrins Enantioseparation
ISSN号	1615-9306
DOI	10.1002/jssc.201501157
文献子类	Article
英文摘要	Cyclodextrins and their derivatives are one of the most common and successful chiral selectors. However, there have been few publications about the use of cyclodextrin-modified monoliths. In this study, organic hybrid monoliths were prepared by the immobilization of derivatized -cyclodextrin alone or with l-2-allylglycine hydrochloride to the polyhedral oligomeric silsesquioxane methacryl substituted monolith. The main topic of this study is a combined system with dual chiral selectors (l-2-allylglycine hydrochloride and -cyclodextrin) as monolithic chiral stationary phase. The effect of l-2-allylglycine hydrochloride concentration on enantioseparation was investigated. The enantioseparation of the four acidic compounds with resolutions up to 2.87 was achieved within 2.5 min on the prepared chiral monolithic column in capillary liquid chromatography. Moreover, the possible mechanism of enantioseparation was discussed.
WOS关键词	POLYHEDRAL OLIGOMERIC SILSESQUIOXANES ; RING-OPENING POLYMERIZATION ; ONE-POT APPROACH ; BETA-CYCLODEXTRIN ; STATIONARY PHASES ; CHIRAL SEPARATIONS ; FUNCTIONAL MONOMER ; FACILE PREPARATION ; ELECTROCHROMATOGRAPHY ; ELECTROPHORESIS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000373617100011
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170694]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Ou, Junjie; Zou, Hanfa
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Szwed, Kamila,Ou, Junjie,Huang, Guang,et al. Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography[J]. JOURNAL OF SEPARATION SCIENCE,2016,39(6):1110-1117.
APA	Szwed, Kamila.,Ou, Junjie.,Huang, Guang.,Lin, Hui.,Liu, Zhongshan.,...&Zou, Hanfa.(2016).Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography.JOURNAL OF SEPARATION SCIENCE,39(6),1110-1117.
MLA	Szwed, Kamila,et al."Preparation of cyclodextrin-modified monolithic hybrid columns for the fast enantioseparation of hydroxy acids in capillary liquid chromatography".JOURNAL OF SEPARATION SCIENCE 39.6(2016):1110-1117.