Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics Bearing a Hydroxyl Group, 3-Hydroxypyridinium Salts

doi:10.1021/acscatal.5b02625

	Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics Bearing a Hydroxyl Group, 3-Hydroxypyridinium Salts
	Huang, Wen-Xue 1; Yu, Chang-Bin 1; Ji, Yue 1; Liu, Lian-Jin 1; Zhou, Yong-Gui 1,2
刊名	ACS CATALYSIS
	2016-04-01
卷号	6 期号:4 页码:2368-2371
关键词	Iridium Asymmetric Hydrogenation 3-hydroxypyridinium Salts Piperidin-3-ol Piperidin-3-one
ISSN号	2155-5435
DOI	10.1021/acscatal.5b02625
文献子类	Article
英文摘要	A highly enantioselective hydrogenation of heteroaromatics bearing a hydroxyl group, 3-hydroxypyridinium salts, has been successfully developed using chiral iridium catalyst, providing a direct access to trans 6-substituted piperidin-3-ols with up to 95% ee. Swern oxidation of the hydrogenation products affords chiral 6-substituted piperidin-3-ones, which are easily reduced to cis 6-substituted piperidin-3-ols using K-selectride.
WOS关键词	HIGHLY ENANTIOSELECTIVE HYDROGENATION ; PYRIDINIUM SALTS ; RING EXPANSION ; QUINOLINES ; DERIVATIVES ; QUINOXALINES ; REDUCTION ; INDOLES ; SCOPE ; ISOQUINOLINES
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000373524400026
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170690]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhou, Yong-Gui
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
推荐引用方式 GB/T 7714	Huang, Wen-Xue,Yu, Chang-Bin,Ji, Yue,et al. Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics Bearing a Hydroxyl Group, 3-Hydroxypyridinium Salts[J]. ACS CATALYSIS,2016,6(4):2368-2371.
APA	Huang, Wen-Xue,Yu, Chang-Bin,Ji, Yue,Liu, Lian-Jin,&Zhou, Yong-Gui.(2016).Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics Bearing a Hydroxyl Group, 3-Hydroxypyridinium Salts.ACS CATALYSIS,6(4),2368-2371.
MLA	Huang, Wen-Xue,et al."Iridium-Catalyzed Asymmetric Hydrogenation of Heteroaromatics Bearing a Hydroxyl Group, 3-Hydroxypyridinium Salts".ACS CATALYSIS 6.4(2016):2368-2371.