Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells

doi:10.1038/srep29858

	Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells
	Liu, Yang 4; Wang, Shujun 5,6; Sun, Dongsheng 4,6; Liu, Yongdong 1; Liu, Yang 4; Wang, Yang 3,4; Liu, Chang 2,4; Wu, Hao 4,6; Lv, Yan 5,6; Ren, Ying 5,6
刊名	SCIENTIFIC REPORTS
	2016-07-19
卷号	6
ISSN号	2045-2322
DOI	10.1038/srep29858
文献子类	Article
英文摘要	Tumor metastasis with resistance to anticancer therapies is the main cause of death in cancer patients. It is necessary to develop reliable tumor metastasis models that can closely recapitulate the pathophysiological features of the native tumor tissue. In this study, chondroitin sulfate (CS)-modified alginate hydrogel beads (ALG-CS) are developed to mimic the in vivo tumor microenvironment with an abnormally increased expression of CS for the promotion of tumor cell metastasis. The modification mechanism of CS on alginate hydrogel is due to the cross-linking between CS and alginate molecules via coordination of calcium ions, which enables ALG-CS to possess significantly different physical characteristics than the traditional alginate beads (ALG). And quantum chemistry calculations show that in addition to the traditional egg-box structure, novel asymmetric egg-box-like structures based on the interaction between these two kinds of polymers are also formed within ALG-CS. Moreover, tumor cell metastasis is significantly enhanced in ALG-CS compared with that in ALG, as confirmed by the increased expression of MMP genes and proteins and greater in vitro invasion ability. Therefore, ALG-CS could be a convenient and effective 3D biomimetic scaffold that would be used to construct standardized tumor metastasis models for tumor research and anticancer drug screening.
WOS关键词	ALGINATE GEL BEADS ; MATRIX METALLOPROTEINASES ; PLASMINOGEN-ACTIVATOR ; BREAST-CANCER ; INCREASED EXPRESSION ; MODEL ; UROKINASE ; CARCINOMA ; CULTURE ; TISSUE
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000379877300001
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/170412]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Sun, Guangwei
作者单位	1.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China 2.Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China 3.Dalian Univ, Sch Life Sci, Dalian 116023, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yang,Wang, Shujun,Sun, Dongsheng,et al. Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells[J]. SCIENTIFIC REPORTS,2016,6.
APA	Liu, Yang.,Wang, Shujun.,Sun, Dongsheng.,Liu, Yongdong.,Liu, Yang.,...&Ma, Xiaojun.(2016).Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells.SCIENTIFIC REPORTS,6.
MLA	Liu, Yang,et al."Development of a Biomimetic Chondroitin Sulfate-modified Hydrogel to Enhance the Metastasis of Tumor Cells".SCIENTIFIC REPORTS 6(2016).