An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103

doi:10.1016/j.carbpol.2016.08.096

	An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103
	Xie, Hongguo 1; Zheng, Huizhen 1,3; Gao, Meng 1,3; Ren, Ying 1,3; Lou, Ruyun 1,3; Yu, Weiting 1; Liu, Xiudong 2; Ma, Xiaojun 1
刊名	CARBOHYDRATE POLYMERS
	2017-01-02
卷号	155 页码:329-335
关键词	Hydrogel Edta-ca-alg Ph-responsive Carrier Lactobacillus Rhamnosus Atcc 53103 Controlled Release
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2016.08.096
文献子类	Article
英文摘要	A pH-responsive carrier based on an ethylenediaminetetraacetic-calcium-alginate (EDTA-Ca-Alg) system was developed by controlling the release of Ca2+. The system remained in the solution state at neutral pH since EDTA completely chelated the Ca2+. In contrast, a hydrogel immediately formed when the pH was below 4.0, which triggered the in situ release of Ca2+ from the EDTA-Ca compound and led to alginate-Ca binding. Taking advantage of the pH sensitivity, we prepared hydrogel microspheres with uniform size to entrap Lactobacillus rhamnosus ATCC 53103 through emulsification. In an acidic environment, the hydrogel structure remained compact with, negligible pores to protect L. rhamnosus ATCC 53103. However, in a neutral intestinal environment, the hydrogel structure gradually disassembled because of the Ca2+ release from the hydrogel, which caused cell release. Therefore, a pH-responsive carrier was developed for the protection and the controlled release of cells in gastrointestinal tract, thus providing potential for oral delivery of probiotics. (C) 2016 Elsevier Ltd. All rights reserved.
WOS关键词	MICROENCAPSULATION ; PROBIOTICS ; ENCAPSULATION ; BACTERIA ; CHITOSAN ; GELATION
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000386402600035
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169964]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yu, Weiting; Liu, Xiudong
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Dalian Univ, Coll Environm & Chem Engn, Dalian Econ Technol Dev Zone, Dalian 116622, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Xie, Hongguo,Zheng, Huizhen,Gao, Meng,et al. An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103[J]. CARBOHYDRATE POLYMERS,2017,155:329-335.
APA	Xie, Hongguo.,Zheng, Huizhen.,Gao, Meng.,Ren, Ying.,Lou, Ruyun.,...&Ma, Xiaojun.(2017).An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103.CARBOHYDRATE POLYMERS,155,329-335.
MLA	Xie, Hongguo,et al."An improved pH-responsive carrier based on EDTA-Ca-alginate for oral delivery of Lactobacillus rhamnosus ATCC 53103".CARBOHYDRATE POLYMERS 155(2017):329-335.