Functional diversity of topological modules in human protein-protein interaction networks

doi:10.1038/s41598-017-16270-z

	Functional diversity of topological modules in human protein-protein interaction networks
	Chu, Hongwei 3,4; Zhou, Xuezhong 1,2; Liu, Guangming 1,2; Wang, Huixin 1,2; Yu, Jian 1,2
刊名	SCIENTIFIC REPORTS
	2017-11-23
卷号	7
ISSN号	2045-2322
DOI	10.1038/s41598-017-16270-z
文献子类	Article
英文摘要	A large-scale molecular interaction network of protein-protein interactions (PPIs) enables the automatic detection of molecular functional modules through a computational approach. However, the functional modules that are typically detected by topological community detection algorithms may be diverse in functional homogeneity and are empirically considered to be default functional modules. Thus, a significant challenge that has been described but not elucidated is investigating the relationship between topological modules and functional modules. We systematically investigated this issue by initially using seven widely used community detection algorithms to partition the PPI network into communities. Four homogeneity measures were subsequently implemented to evaluate the functional homogeneity of protein community. We determined that a significant portion of topological modules with heterogeneous functionality exists and should be further investigated; moreover, these findings indicated that topologically based functional module detection approaches must be reconsidered. Furthermore, we found that the functional homogeneity of topological modules is positively correlated with their edge densities, degree of association with diseases and general Gene Ontology (GO) terms. Thus, topologically based module detection approaches should be used with caution in the identification of functional modules with high homogeneity
WOS关键词	HUMAN-DISEASE NETWORK ; BIOLOGICAL NETWORKS ; ORGANIZATION ; IDENTIFICATION ; COMMUNITIES ; INTEGRATION ; COMPLEXES ; MEDICINE ; DATABASE ; GENES
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000416129800029
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169282]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhou, Xuezhong; Yu, Jian
作者单位	1.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Beijing 100044, Peoples R China 2.Beijing Jiaotong Univ, Beijing Key Lab Traff Data Anal & Min, Beijing 100044, Peoples R China 3.Dalian Univ Technol, Dalian 116024, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Chu, Hongwei,Zhou, Xuezhong,Liu, Guangming,et al. Functional diversity of topological modules in human protein-protein interaction networks[J]. SCIENTIFIC REPORTS,2017,7.
APA	Chu, Hongwei,Zhou, Xuezhong,Liu, Guangming,Wang, Huixin,&Yu, Jian.(2017).Functional diversity of topological modules in human protein-protein interaction networks.SCIENTIFIC REPORTS,7.
MLA	Chu, Hongwei,et al."Functional diversity of topological modules in human protein-protein interaction networks".SCIENTIFIC REPORTS 7(2017).