Detection of Amino Acids and Polypeptides by Electrospray Ionization-Ion Mobility Spectrometry

doi:10.11895/j.issn.0253.3820.171052

	Detection of Amino Acids and Polypeptides by Electrospray Ionization-Ion Mobility Spectrometry
	Chen Chuang 2; Li Hai-Yang 2; Kong Jing-Lin 1; Liu Wei-Wei 1; Ding Jun-Jie 1; Zhang Lin 1; Li Bao-Qiang 1; Qin Mo-Lin 1
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2017-11-01
卷号	45 期号:11 页码:1583-1588
关键词	Electrospray Ion Mobility Spectrometry Amino Acid Polypeptide Reduced Mobility
ISSN号	0253-3820
DOI	10.11895/j.issn.0253.3820.171052
文献子类	Article
英文摘要	The electrospray ionization. ion mobility spectrometric (ESI-IMS) technique has the potential as an analytical separation tool in analyzing polypeptides and amino acids for fast screening unknown samples in anti-chemical and biological terror attacks. A method for detecting several polypeptides and amino acids was developed based on ESI-IMS using air as drift gas at room temperature. The ion mobility of four amino acids and two polypeptides dissolved in methanol was determined on the system at elution rate of 2 mu L/min. The spectra of these compounds had characteristics of finger-printing maps. The limit of detection of this instrument for Substance P could reach 855 ng/mL in 1 min. The results showed that a small, self-contained ESI-IMS instrument with reservoirs of air could be used to quickly detect and accurately identify polypeptides and amino acids.
WOS关键词	PERFORMANCE ; SEPARATION ; ISOMERS
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000419177900001
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169212]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Kong Jing-Lin
作者单位	1.Inst Chem Def, Beijing 102205, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Chen Chuang,Li Hai-Yang,Kong Jing-Lin,et al. Detection of Amino Acids and Polypeptides by Electrospray Ionization-Ion Mobility Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2017,45(11):1583-1588.
APA	Chen Chuang.,Li Hai-Yang.,Kong Jing-Lin.,Liu Wei-Wei.,Ding Jun-Jie.,...&Qin Mo-Lin.(2017).Detection of Amino Acids and Polypeptides by Electrospray Ionization-Ion Mobility Spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,45(11),1583-1588.
MLA	Chen Chuang,et al."Detection of Amino Acids and Polypeptides by Electrospray Ionization-Ion Mobility Spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 45.11(2017):1583-1588.