Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex

doi:10.1002/pmic.201700408

	Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex
	Lozano-Montes, Laura 1; Papilloud, Aurelie 2; Zhao, Nan 3; Ye, Xueting 3; Zhang, Xiaozhe 3; Sandi, Carmen 2; Rainer, Gregor 1; Li, Wenxue 1
刊名	PROTEOMICS
	2018-04-01
卷号	18 期号:7
关键词	Adulthood Stress Anxiety Depression Differential Analysis Hippocampus Neuropeptides Peripuberty Stress Prefrontal Cortex
ISSN号	1615-9853
DOI	10.1002/pmic.201700408
文献子类	Article
英文摘要	Adverse life experiences increase the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive-like symptoms following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully characterized. Neuropeptides play an important role as signaling molecules that contribute to physiological regulation and have been linked to neurological and psychiatric diseases. However, little is known about the influence of stress on neuropeptide regulation in the brain. Here, we have performed an exploratory study of how neuropeptide expression at adulthood is modulated by experiencing a period of multiple stressful experiences. We have targeted hippocampus and prefrontal cortex (PFC) brain areas, which have previously been shown to be modulated by stressors, employing a targeted liquid chromatography-mass spectrometry (LC-MS) based approach that permits broad peptide coverage with high sensitivity. We found that in the hippocampus, Met-enkephalin, Met-enkephalin-Arg-Phe, and Met-enkephalin-Arg-Gly-Leu were upregulated, while Leu-enkephalin and Little SAAS were downregulated after stress. In the PFC area, Met-enkephalin-Arg-Phe, Met-enkephalin-Arg-Gly-Leu, peptide PHI-27, somatostatin-28 (AA1-12), and Little SAAS were all downregulated. This systematic evaluation of neuropeptide alterations in the hippocampus and PFC suggests that stressors impact neuropeptides and that neuropeptide regulation is brain-area specific. These findings suggest several potential peptide candidates, which warrant further investigations in terms of correlation with depression-associated behaviors.
WOS关键词	VASOACTIVE INTESTINAL POLYPEPTIDE ; MAJOR DEPRESSIVE DISORDER ; EARLY-LIFE STRESS ; RESTRAINT STRESS ; INCREASED AGGRESSION ; PERIPUBERTY STRESS ; SOCIAL DEFICITS ; ANXIETY ; CHOLECYSTOKININ ; BRAIN
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	WILEY
WOS记录号	WOS:000428733300006
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/169092]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhang, Xiaozhe
作者单位	1.Univ Fribourg, Dept Med, Fribourg, Switzerland 2.Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Behav Genet, Lausanne, Switzerland 3.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biol Technol, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Lozano-Montes, Laura,Papilloud, Aurelie,Zhao, Nan,et al. Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex[J]. PROTEOMICS,2018,18(7).
APA	Lozano-Montes, Laura.,Papilloud, Aurelie.,Zhao, Nan.,Ye, Xueting.,Zhang, Xiaozhe.,...&Li, Wenxue.(2018).Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex.PROTEOMICS,18(7).
MLA	Lozano-Montes, Laura,et al."Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex".PROTEOMICS 18.7(2018).