Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma

doi:10.1158/1078-0432.CCR-17-1707

	Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma
	Tang, Ling 2,3,4; Zeng, Jun 3,5; Geng, Pengyu 2; Fang, Chengnan 3; Wang, Yang 2,4; Sun, Mingju 2; Wang, Changsong 6,7; Wang, Jiao 4; Yin, Peiyuan 3; Hu, Chunxiu 3
刊名	CLINICAL CANCER RESEARCH
	2018-01-15
卷号	24 期号:2 页码:474-485
ISSN号	1078-0432
DOI	10.1158/1078-0432.CCR-17-1707
文献子类	Article
英文摘要	Purpose: Metabolic reprogramming is frequently identified in hepatocellular carcinoma (HCC), which is the most common type of liver malignancy. The reprogrammed cellular metabolisms promote tumor cell survival, proliferation, angiogenesis, and metastasis. However, the mechanisms of this process remain unclear in HCC.
WOS关键词	CANCER-CELLS ; C-MYC ; SORAFENIB RESISTANCE ; GLUTAMINE-METABOLISM ; TUMOR-SUPPRESSOR ; INHIBITION ; PROLIDASE ; GROWTH ; PROTEIN ; LIVER
WOS研究方向	Oncology
语种	英语
出版者	AMER ASSOC CANCER RESEARCH
WOS记录号	WOS:000422883900022
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/168548]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Xu, Guowang; Liu, Yang
作者单位	1.NINDS, Surg Neurol Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Sci Res Ctr Translat Med, Dalian, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 4.Dalian Univ, Sch Life Sci, Dalian, Peoples R China 5.Univ Chinese Acad Sci, Dalian, Peoples R China 6.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Heilongjiang, Peoples R China 7.Harbin Med Univ, Affiliated Hosp 3, Dept Crit Care Med, Harbin, Heilongjiang, Peoples R China 8.Univ Cincinnati, Dept Med, Div Pulm Crit Care & Sleep Med, Cincinnati, OH USA
推荐引用方式 GB/T 7714	Tang, Ling,Zeng, Jun,Geng, Pengyu,et al. Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma[J]. CLINICAL CANCER RESEARCH,2018,24(2):474-485.
APA	Tang, Ling.,Zeng, Jun.,Geng, Pengyu.,Fang, Chengnan.,Wang, Yang.,...&Liu, Yang.(2018).Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.CLINICAL CANCER RESEARCH,24(2),474-485.
MLA	Tang, Ling,et al."Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma".CLINICAL CANCER RESEARCH 24.2(2018):474-485.