Gold(I)-Catalyzed Polycyclization of Linear Dienediynes to Seven-Membered Ring-Containing Polycycles via Tandem Cyclopropanation/Cope Rearrangement/C-H Activation

doi:10.1021/ol5028706

	Gold(I)-Catalyzed Polycyclization of Linear Dienediynes to Seven-Membered Ring-Containing Polycycles via Tandem Cyclopropanation/Cope Rearrangement/C-H Activation
	Cai, Pei-Jun; Wang, Yi; Liu, Cheng-Hang; Yu, Zhi-Xiang
刊名	ORGANIC LETTERS
	2014-11-21
卷号	16 期号:22 页码:5898-5901
ISSN号	1523-7060
DOI	10.1021/ol5028706
文献子类	Article
英文摘要	A novel gold(I)-catalyzed polycyclization of easily prepared linear dienediynes has been developed for the construction of fused 5,7,6-tricyclic ring systems in one step with high diastereocontrol. The polycyclization, a formal [4 + 3]/CH activation reaction, takes place through gold(I)-catalyzed intramolecular cyclopropanation of diene with diyne, Cope rearrangement of cis-alkenylalkynylcyclopropane, aliphatic CH activation via a seven-membered-ring allene intermediate, and [1,2]-H and -G (H or OAc) shifts.
WOS关键词	NATURAL-PRODUCT SYNTHESIS ; RUTHENIUM-CATALYZED CYCLOPROPANATION ; DUAL GOLD CATALYSIS ; STEREOSELECTIVE CONSTRUCTION ; BOND FUNCTIONALIZATION ; PROPARGYLIC ESTERS ; ORGANIC-SYNTHESIS ; HIGHLY EFFICIENT ; FACILE FORMATION ; CARBENE COMPLEX
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000345470000019
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/167330]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Yu, Zhi-Xiang
作者单位	Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Coll Chem,BNLMS, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Cai, Pei-Jun,Wang, Yi,Liu, Cheng-Hang,et al. Gold(I)-Catalyzed Polycyclization of Linear Dienediynes to Seven-Membered Ring-Containing Polycycles via Tandem Cyclopropanation/Cope Rearrangement/C-H Activation[J]. ORGANIC LETTERS,2014,16(22):5898-5901.
APA	Cai, Pei-Jun,Wang, Yi,Liu, Cheng-Hang,&Yu, Zhi-Xiang.(2014).Gold(I)-Catalyzed Polycyclization of Linear Dienediynes to Seven-Membered Ring-Containing Polycycles via Tandem Cyclopropanation/Cope Rearrangement/C-H Activation.ORGANIC LETTERS,16(22),5898-5901.
MLA	Cai, Pei-Jun,et al."Gold(I)-Catalyzed Polycyclization of Linear Dienediynes to Seven-Membered Ring-Containing Polycycles via Tandem Cyclopropanation/Cope Rearrangement/C-H Activation".ORGANIC LETTERS 16.22(2014):5898-5901.