Total Syntheses of Menisporphine and Daurioxoisoporphine C Enabled by Photoredox-Catalyzed Direct C-H Arylation of Isoquinoline with Aryldiazonium Salt

doi:10.1021/jo5020432

	Total Syntheses of Menisporphine and Daurioxoisoporphine C Enabled by Photoredox-Catalyzed Direct C-H Arylation of Isoquinoline with Aryldiazonium Salt
	Zhang, Jing 2,3; Chen, Jie 2,3; Zhang, Xiaoyun 3; Lei, Xiaoguang 1,3,4
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2014-11-07
卷号	79 期号:21 页码:10682-10688
ISSN号	0022-3263
DOI	10.1021/jo5020432
文献子类	Article
英文摘要	Isoquinoline alkaloids are attractive natural products due to their diverse chemical structures as well as remarkable bioactivities. Herein, we report the concise total syntheses of two isoquinoline alkaloids, menisporphine and daurioxoisoporphine C, through a mild and efficient photoredox-catalyzed direct C-H arylation of isoquinoline core with aryldiazonium salt. This new strategy is complementary to the conventional isoquinoline synthesis and would provide us a useful means to achieve a more convergent and flexible approach to access diverse isoquinoline structures.
WOS关键词	VISIBLE-LIGHT PHOTOCATALYSIS ; BISCHLER-NAPIERALSKI REACTION ; ARYL DIAZONIUM SALTS ; BOND FORMATION ; ENANTIOSELECTIVE SYNTHESIS ; MENISPERMUM-DAURICUM ; HETEROAROMATIC BASES ; CONVENIENT SYNTHESIS ; RADICAL ADDITIONS ; METAL-FREE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000344638200075
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/167312]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Lei, Xiaoguang
作者单位	1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci,Synthet & Funct Biomol C, Minist Educ,Dept Chem Biol,Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China 3.Natl Inst Biol Sci NIBS, Beijing 102206, Peoples R China 4.Peking Univ, Ctr Life Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jing,Chen, Jie,Zhang, Xiaoyun,et al. Total Syntheses of Menisporphine and Daurioxoisoporphine C Enabled by Photoredox-Catalyzed Direct C-H Arylation of Isoquinoline with Aryldiazonium Salt[J]. JOURNAL OF ORGANIC CHEMISTRY,2014,79(21):10682-10688.
APA	Zhang, Jing,Chen, Jie,Zhang, Xiaoyun,&Lei, Xiaoguang.(2014).Total Syntheses of Menisporphine and Daurioxoisoporphine C Enabled by Photoredox-Catalyzed Direct C-H Arylation of Isoquinoline with Aryldiazonium Salt.JOURNAL OF ORGANIC CHEMISTRY,79(21),10682-10688.
MLA	Zhang, Jing,et al."Total Syntheses of Menisporphine and Daurioxoisoporphine C Enabled by Photoredox-Catalyzed Direct C-H Arylation of Isoquinoline with Aryldiazonium Salt".JOURNAL OF ORGANIC CHEMISTRY 79.21(2014):10682-10688.