Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation

doi:10.1002/adma.201803299

	Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation
	Wang, Shutao 1,2; Chen, Cheng 1,3; Liang, Xinmiao 3; Song, Yongyang 1,2; Li, Xiuling 3; Fan, Jun-Bing 2; Kang, Hongjian 1,3; Zhang, Xiaofei 3
刊名	ADVANCED MATERIALS
	2018-09-26
卷号	30 期号:39 页码:8
关键词	emulsion interfacial polymerization glycopeptide separation heterostructured nanopores porous particles
ISSN号	0935-9648
DOI	10.1002/adma.201803299
通讯作者	Liang, Xinmiao(liangxm@dicp.ac.cn) ; Wang, Shutao(stwang@mail.ipc.ac.cn)
英文摘要	Porous polymer materials are extensively used for biomolecule separation. However, conventional homogeneous porous polymer materials cannot efficiently separate specific low-abundance biomolecules from complex samples. Here, particles fabricated by emulsion interfacial polymerization featuring heterostructured nanopores with tunable size are reported, which can be used to realize low-abundance glycopeptide (GP) separation from complex biofluids. The heterostructured surface inside the nanopores allows solvent-dependent local adsorption of biomolecules onto hydrophilic or hydrophobic regions. Low-abundance hydrophilic GPs in complex biofluids can be efficiently separated via the hydrophilic region of nanopores in low-polarity solvent after the hydrophobic region removes high-abundance hydrophobic proteins and non-glycopeptides in high-polarity solvent. It is expected that these particles with heterostructured nanopores can be used for separation of nucleic acids, saccharides, and proteins, and downstream clinical diagnosis.
资助项目	National Natural Science Foundation of China[21425314] ; National Natural Science Foundation of China[21775148] ; National Natural Science Foundation of China[21504098] ; National Natural Science Foundation of China[51533007] ; National Natural Science Foundation of China[21434009] ; National Natural Science Foundation of China[21475129] ; Key Research Program of the Chinese Academy of Sciences[KJZD-EW-M01] ; MOST[2013YQ190467] ; Beijing Municipal Science & Technology Commission[Z161100000116037] ; Top-Notch Young Talents Program of China
WOS关键词	ALZHEIMERS-DISEASE ; MESOPOROUS SILICA ; MASS-SPECTROMETRY ; BETA-PEPTIDE ; PLASMID DNA ; CHROMATOGRAPHY ; PROTEIN ; EXTRACTION ; ENRICHMENT ; PURIFICATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000445327500022
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166994]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Wang, Shutao; Liang, Xinmiao
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Bioinspired Mat & Interfacial Sci, CAS Ctr Excellence Nanosci Tech Inst Phys & Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shutao,Chen, Cheng,Liang, Xinmiao,et al. Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation[J]. ADVANCED MATERIALS,2018,30(39):8.
APA	Wang, Shutao.,Chen, Cheng.,Liang, Xinmiao.,Song, Yongyang.,Li, Xiuling.,...&Zhang, Xiaofei.(2018).Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation.ADVANCED MATERIALS,30(39),8.
MLA	Wang, Shutao,et al."Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation".ADVANCED MATERIALS 30.39(2018):8.