Current and future perspectives of functional metabolomics in disease studies-A review

doi:10.1016/j.aca.2018.04.006

	Current and future perspectives of functional metabolomics in disease studies-A review
	Xu, Guowang 1,2; Yan, Min 1,2,3
刊名	ANALYTICA CHIMICA ACTA
	2018-12-11
卷号	1037 页码:41-54
关键词	Functional metabolomics Metabolomics Biological platform Cell metabolism Mass spectrometry
ISSN号	0003-2670
DOI	10.1016/j.aca.2018.04.006
通讯作者	Xu, Guowang(xugw@dicp.ac.cn)
英文摘要	Functional metabolomics is a new concept, which studies the functions of metabolites and related enzymes focused on metabolomics. It overcomes the shortcomings of traditional discovery metabolomics of mainly relying on literatures for biological interpretation. Functional metabolomics has many advantages. Firstly, the functional roles of metabolites and related metabolic enzymes are focused. Secondly, the in vivo and in vitro experiments are conducted to validate the metabolomics findings, therefore, increasing the reliability of metabolomics study and producing the new knowledge. Thirdly, functional metabolomics can be used by biologists to investigate functions of metabolites, and related genes and proteins. In this review, we summarize the analytical, biological and clinical platforms used in functional metabolomics studies. Recent progresses of functional metabolomics in cancer, metabolic diseases and biological phenotyping are reviewed, and future development is also predicted. Because of the tremendous advantages of functional metabolomics, it will have a bright future. (c) 2018 Elsevier B.V. All rights reserved.
资助项目	National Key Research and Development Program of China[2017YFC0906900] ; National Key Research and Development Program of China[2016YFC0903302] ; National Natural Science Foundation of China[81472374] ; National Natural Science Foundation of China[21435006] ; innovation program of science and research from the DICP, CAS[DICP TMSR201601]
WOS关键词	CHROMATOGRAPHY-MASS-SPECTROMETRY ; CHAIN AMINO-ACIDS ; METABOLITE IDENTIFICATION APPLICATION ; ISOTOPE RESOLVED METABOLOMICS ; GC/MS-BASED METABOLOMICS ; RATIO OUTLIER ANALYSIS ; NMR-BASED METABOLOMICS ; LABELING LC-MS ; LIQUID-CHROMATOGRAPHY ; TARGETED METABOLOMICS
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000446225000005
资助机构	National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166838]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Xu, Guowang
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Xu, Guowang,Yan, Min. Current and future perspectives of functional metabolomics in disease studies-A review[J]. ANALYTICA CHIMICA ACTA,2018,1037:41-54.
APA	Xu, Guowang,&Yan, Min.(2018).Current and future perspectives of functional metabolomics in disease studies-A review.ANALYTICA CHIMICA ACTA,1037,41-54.
MLA	Xu, Guowang,et al."Current and future perspectives of functional metabolomics in disease studies-A review".ANALYTICA CHIMICA ACTA 1037(2018):41-54.