An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface

doi:10.1039/c8cc09382b

	An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface
	Liu, Yan 1; Li, Can 1; Liu, Xianghui 1,2; Wang, Kai 1,2; Guo, Wengang 1
刊名	CHEMICAL COMMUNICATIONS
	2019-03-04
卷号	55 期号:18 页码:2668-2671
ISSN号	1359-7345
DOI	10.1039/c8cc09382b
通讯作者	Liu, Yan(yanliu503@dicp.ac.cn) ; Li, Can(canli@dicp.ac.cn)
英文摘要	Based on an efficient method for in situ generation of N-o-QM species in the presence of a base, enantioselective catalytic conjugated additions of tritylthiol to in situ generated N-o-QMs are reported. Acid-base bifunctional organocatalyst 4c (10 mol%) enables these transformations with high stereoselectivities (up to 94% ee) using H2O/DCM as a solvent under mild conditions.
资助项目	National Natural Science Foundation of China[21871254] ; National Natural Science Foundation of China[21532006] ; National Natural Science Foundation of China[21472187] ; DICP[DICP ZZBS201602]
WOS关键词	ENANTIOSELECTIVE 4+2 CYCLOADDITION ; HYDROXYBENZYL ALCOHOLS ; ORTHO-XYLYLENES ; ACID CATALYSIS ; ROUTE ; TRIARYLMETHANES ; ANNULATION ; ENAMIDES ; INDOLES ; ACCESS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000459737100017
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; DICP ; DICP
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/166036]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Liu, Yan; Li, Can
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yan,Li, Can,Liu, Xianghui,et al. An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface[J]. CHEMICAL COMMUNICATIONS,2019,55(18):2668-2671.
APA	Liu, Yan,Li, Can,Liu, Xianghui,Wang, Kai,&Guo, Wengang.(2019).An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface.CHEMICAL COMMUNICATIONS,55(18),2668-2671.
MLA	Liu, Yan,et al."An organic-base catalyzed asymmetric 1,4-addition of tritylthiol to in situ generated aza-o-quinone methides at the H2O/DCM interface".CHEMICAL COMMUNICATIONS 55.18(2019):2668-2671.