Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs
Ito, Yoichiro1; Guo, Zengjun5; Zhang, Yan2; Dang, Jun3; Wang, Sicen5; Zhang, Hui5; Xian, Liang5; Tadesse, Nigatu4; Jin, Ming5; Zhang, Xinxin5
刊名REGULATORY TOXICOLOGY AND PHARMACOLOGY
2017-12-01
卷号91页码:58-67
关键词Dioscorea Zingiberensis Ch Wright Steroid Saponins Sub-acute Toxicity Chronic Toxicity
ISSN号0273-2300
DOI10.1016/j.yrtph.2017.10.014
文献子类Article
英文摘要Sub-acute and chronic toxic effects of total steroidal saponins (TSSN) extracts from Dioscorea zingiberensis C.H. Wright on various internal organs and biochemical indicators have never been studied before and this study is the first of its kind to demonstrate sub-acute and chronic toxicities of TSSN on dogs. Administration of TSSN extracts at doses up to 3000 mg/Kg daily for 14 days, no biochemical and organ changes were observed on the experimental groups of dogs. Further, chronic toxicity study through oral administration of TSSN extracts at the gradual doses of 50, 250 and 500 mg/Kg for 90 days followed by a 2-week recovery assay revealed absence of significant architectural and morphological changes in internal organs which were confirmed through histopathological examination and merely no significant alteration in the biochemical indicators including hematologic and urine analysis and electrocardiogram compared to the control dogs. This toxicological evaluation came across with the finding that the herbal preparation can be considered as nontoxic and animals could tolerate the extracts at doses up to 500 mg/Kg with LD50 greater than 3000 mg/Kg. It may serve as a preliminary scientific evidence for further therapeutic investigations.
WOS关键词C. H. WRIGHT ; TANDEM MASS-SPECTROMETRY ; SUBCHRONIC TOXICITY ; HPLC-MS/MS ; RAT PLASMA ; DIOSGENIN ; MEDICINE ; CHWRIGHT ; LEAVES ; MICE
WOS研究方向Legal Medicine ; Pharmacology & Pharmacy ; Toxicology
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000417116400007
资助机构National Natural Science Foundation of China(81603267) ; Fundamental Research Funds for the Central Universities ; China Postdoctoral Science Foundation (First-class)(2016M590958) ; Scientific Research Supporting Project for New Teacher of Xi'an Jiaotong University(1191320023) ; Natural Science Foundation of Shaanxi Province(2015JQ2048 ; Key Laboratory of Tibetan Medicine Research, Chinese Academy of Sciences, Qinghai Province(2017-002) ; Shaanxi Health and Family Planning Commission(2016D089) ; 2016JM8075 ; 2017JQ8017)
内容类型期刊论文
源URL[http://ir.nwipb.ac.cn/handle/363003/13289]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者Ito, Yoichiro; Guo, Zengjun
作者单位1.NHLBI, Lab Bioseparat Technol, Biochem & Biophys Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA
2.Xian Med Univ, Xian 710021, Shaanxi, Peoples R China
3.Chinese Acad Sci, Key Lab Tibetan Med Res, Northwest Inst Plateau Biol, Xining, Qinghai, Peoples R China
4.Xi An Jiao Tong Univ, Sch Int Educ, Xian 710061, Shaanxi, Peoples R China
5.Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta Rd, Xian 710061, Shaanxi, Peoples R China
推荐引用方式
GB/T 7714
Ito, Yoichiro,Guo, Zengjun,Zhang, Yan,et al. Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs[J]. REGULATORY TOXICOLOGY AND PHARMACOLOGY,2017,91:58-67.
APA Ito, Yoichiro.,Guo, Zengjun.,Zhang, Yan.,Dang, Jun.,Wang, Sicen.,...&Zhang, Xinxin.(2017).Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs.REGULATORY TOXICOLOGY AND PHARMACOLOGY,91,58-67.
MLA Ito, Yoichiro,et al."Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis CH Wright: Sub-acute and chronic toxicity studies on dogs".REGULATORY TOXICOLOGY AND PHARMACOLOGY 91(2017):58-67.
个性服务
查看访问统计
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。


©版权所有 ©2017 CSpace - Powered by CSpace