Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments

	Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments
	Guo, Xinyi ; Xie, Ling ; Zhang, Xuze ; Ji, Yinfa ; Chen, Juan ; Pang, Bo ; Xu, Yongtao ; Qi, Delin ; Guo, Songchang
刊名	INTEGRATIVE ZOOLOGY
	2016-03-01
英文摘要	Fishes harbor a huge resource of phenotypic diversity and are useful for understanding the genetic basis of morphological variation. However, it is difficult to transfer classical genetic mapping to most non-model species. In this study, we performed a comparative sequence analysis of Fgfr1a to first interpret the evolution of this candidate scale-loss gene in 15 schizothoracine fishes with various scale phenotypes. While considerable amino acid (AA) substitutions were observed, molecular evolution analysis indicates that the overall coding regions were subject to functional constraint. We also identified extra copies of Fgfr1a in 4 scale-loss fishes and detected accelerated evolution in one AA substitution specific to these duplicates. We speculate that Fgfr1a had accumulated mutations in the ancestral lineage of scale-loss schizothoracine fishes before experiencing duplication events, which was further followed by the diversification of species. In silico mutation analysis predicted deleterious effects of the mutations while no disruptive molecular mechanism was detected. Collectively, our results highlight the important role of Fgfr1a gene in the adaptive evolution of schizothoracine fishes during their radiation in the Qinghai-Tibetan Plateau.
内容类型	期刊论文
源URL	[http://ir.nwipb.ac.cn/handle/363003/5728]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Guo, Xinyi,Xie, Ling,Zhang, Xuze,et al. Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments[J]. INTEGRATIVE ZOOLOGY,2016.
APA	Guo, Xinyi.,Xie, Ling.,Zhang, Xuze.,Ji, Yinfa.,Chen, Juan.,...&Guo, Songchang.(2016).Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments.INTEGRATIVE ZOOLOGY.
MLA	Guo, Xinyi,et al."Signatures of functional constraint at Fgfr1a Genes in schizothoracine fishes (Pisces: Cypriniformes): The dermal skeleton variation adapted to high-altitude environments".INTEGRATIVE ZOOLOGY (2016).