| The alterations of energy metabolism-related protein patterns in brown adipose tissue of rats during cold-induced thermogenesis | |
| Yang Yue1,2; Gong Wei1,2; Wang Wei-Wei1,2; Yu Xiao-Min1; Hu Song-Nian1; Yu Jun1 | |
| 刊名 | Progress in biochemistry and biophysics
 |
| 2010-10-01 | |
| 卷号 | 37期号:10页码:1108-1119 |
| 关键词 | Brown adipose tissue Cold acclimation Thermogenesis Coenzyme q |
| ISSN号 | 1000-3282 |
| DOI | 10.3724/sp.j.1206.2010.00231 |
| 通讯作者 | Yu jun(junyu@big.ac.cn) |
| 英文摘要 | The physiological role of brown adipose tissue (bat) is quite different from that of white adipose tissue (wat) by dissipating energy as heat instead of generating atp mitochondrion is an essential organelle that plays a crucial role in energy production and cellular homeostasis to gain a better understanding of energy metabolism in bat, mitochondria were isolated and a systematic analysis of protein patterns was performed in wat and bat of rat with two-dimensional gel electrophoresis differentially expressed proteins were identified using mass spectrometry and it was found that the proteins involved in lipid and amino acid metabolisms, tca cycle, and respiratory chain are more abundant in bat than in wat, which are further up-regulated in response to cold exposure in bat furthermore, the study reveals, for the first time, a subset of coq genes required for coenzyme q biosynthesis are significantly up-regulated after cold exposure in bat these findings suggest that coenzyme q increase is implicated in the non-shivering thermogenesis and contribute new data for understanding the unique process of energy metabolism in bat |
| WOS关键词 | DIET-INDUCED THERMOGENESIS ; UNCOUPLING PROTEIN ; COENZYME-Q ; UBIQUINONE BIOSYNTHESIS ; MESSENGER-RNA ; CAENORHABDITIS-ELEGANS ; GENE-EXPRESSION ; TRANSGENIC MICE ; FAT ; WHITE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| 出版者 | CHINESE ACAD SCIENCES, INST BIOPHYSICS |
| WOS记录号 | WOS:000283673200009 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2415503 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu Jun |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang Yue,Gong Wei,Wang Wei-Wei,et al. The alterations of energy metabolism-related protein patterns in brown adipose tissue of rats during cold-induced thermogenesis[J]. Progress in biochemistry and biophysics,2010,37(10):1108-1119. |
| APA | Yang Yue,Gong Wei,Wang Wei-Wei,Yu Xiao-Min,Hu Song-Nian,&Yu Jun.(2010).The alterations of energy metabolism-related protein patterns in brown adipose tissue of rats during cold-induced thermogenesis.Progress in biochemistry and biophysics,37(10),1108-1119. |
| MLA | Yang Yue,et al."The alterations of energy metabolism-related protein patterns in brown adipose tissue of rats during cold-induced thermogenesis".Progress in biochemistry and biophysics 37.10(2010):1108-1119. |
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