| Human functional genetic studies are biased against the medically most relevant primate-specific genes | |
| Hao, Lili1,2; Ge, Xiaomeng1; Wan, Haolei1; Hu, Songnian1; Lercher, Martin J.3; Yu, Jun1; Chen, Wei-Hua4 | |
| 刊名 | Bmc evolutionary biology
 |
| 2010-10-20 | |
| 卷号 | 10页码:8 |
| ISSN号 | 1471-2148 |
| DOI | 10.1186/1471-2148-10-316 |
| 通讯作者 | Yu, jun(junyu@big.ac.cn) |
| 英文摘要 | Background: many functional, structural and evolutionary features of human genes have been observed to correlate with expression breadth and/or gene age. here, we systematically explore these correlations. results: gene age and expression breadth are strongly correlated, but contribute independently to the variation of functional, structural and evolutionary features, even when we take account of variation in mrna expression level. human genes without orthologs in distant species ('young' genes) tend to be tissue-specific in their expression. as computational inference of gene function often relies on the existence of homologs in other species, and experimental characterization is facilitated by broad and high expression, young, tissue-specific human genes are often the least characterized. at the same time, young genes are most likely to be medically relevant. conclusions: our results indicate that functional characterization of human genes is biased against young, tissue-specific genes that are mostly medically relevant. the biases should not be taken lightly because they may pose serious obstacles to our understanding of the molecular basis of human diseases. future studies should thus be designed to specifically explore the properties of primate-specific genes. |
| WOS关键词 | EVOLUTIONARY ORIGIN ; TISSUE-SPECIFICITY ; EXPRESSION ; ONTOLOGY |
| WOS研究方向 | Evolutionary Biology ; Genetics & Heredity |
| WOS类目 | Evolutionary Biology ; Genetics & Heredity |
| 语种 | 英语 |
| 出版者 | BIOMED CENTRAL LTD |
| WOS记录号 | WOS:000285338500002 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2410203 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Jun |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Gen, CAS Key Lab Genome Sci & Informat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Univ Dusseldorf, Bioinformat Grp, D-40225 Dusseldorf, Germany 4.European Mol Biol Lab, D-69117 Heidelberg, Germany |
| 推荐引用方式 GB/T 7714 | Hao, Lili,Ge, Xiaomeng,Wan, Haolei,et al. Human functional genetic studies are biased against the medically most relevant primate-specific genes[J]. Bmc evolutionary biology,2010,10:8. |
| APA | Hao, Lili.,Ge, Xiaomeng.,Wan, Haolei.,Hu, Songnian.,Lercher, Martin J..,...&Chen, Wei-Hua.(2010).Human functional genetic studies are biased against the medically most relevant primate-specific genes.Bmc evolutionary biology,10,8. |
| MLA | Hao, Lili,et al."Human functional genetic studies are biased against the medically most relevant primate-specific genes".Bmc evolutionary biology 10(2010):8. |
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